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Blokada immunologicznych punktów kontrolnych w immunoterapii

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Komórki dendrytyczne i kontrola odporności.

Limfocitele B și T   sunt mediatorii imunității, dar funcția lor este sub controlul celulelor dendritice  . Dendritlce  celulele  din antigeni de captare și de proces periferie, exprimă  limfocite  molecule co-stimulatoare, migrează spre organele limfoide si citokine secreta pentru a initia raspunsuri imune. Acestea activează nu numai  limfocitele , ci tolerează și celulele T   la antigene care sunt înnăscute în organism (auto-antigene), reducând astfel reacțiile autoimune. Odată ce un  tip de celulă neglijat  , celulele dendritice   pot fi acum obținute cu ușurință în cantități suficiente pentru a permite molecula și  celula analiza biologică. Odată cu cunoașterea vine realizarea că aceste  celule  sunt un instrument puternic pentru manipularea sistemului imunitar.

Poprawa czasu przeżycia przy stosowaniu ipilimumabu u pacjentów z przerzutowym czerniakiem.

 

FUNDAL

O îmbunătățire a supraviețuirii globale în rândul pacienților cu melanom metastatic a fost un obiectiv evaziv. În acest studiu de fază 3, ipilimumab – care blochează antigenul asociat four al limfocitelor T citotoxice pentru a potența un  răspuns antitumoral al celulelor T – administrat cu sau fără un vaccin peptidic cu glicoproteină 100 (gp100) a fost comparat cu gp100 singur la pacienții cu metastază tratată anterior melanom.

METODE

Un whole de 676 de pacienți HLA-A * 0201 pozitivi cu melanom de stadiul III sau IV irezecabil, a căror boală progresase în timp ce primeau terapie pentru boala metastatică, au fost repartizați aleatoriu, într-un raport de 3: 1: 1, pentru a primi ipilimumab plus gp100 (403 pacienți) , ipilimumab singur (137) sau gp100 singur (136). Ipilimumab, la o doză de Three mg per kilogram de greutate corporală, a fost administrat cu sau fără gp100 la fiecare Three săptămâni pentru până la patru tratamente (inducție). Pacienții eligibili ar putea primi terapie de reinducție. Obiectivul principal a fost supraviețuirea generală.

REZULTATE

Supraviețuirea globală mediană a fost de 10,Zero luni la pacienții cărora li s-a administrat ipilimumab plus gp100, comparativ cu 6,four luni la pacienții cărora li s-a administrat gp100 singur (raport de risc pentru deces, 0,68; P <0,001). Supraviețuirea globală mediană numai cu ipilimumab a fost de 10,1 luni (raportul de risc pentru deces în comparație cu gp100 singur, 0,66; P = 0,003). Nu s-a detectat nicio diferență în supraviețuirea globală între grupurile de ipilimumab (raportul de risc cu ipilimumab plus gp100, 1,04; P = 0,76). Evenimentele adversarial legate de imunitate de gradul Three sau four au apărut la 10-15% dintre pacienții tratați cu ipilimumab și la 3% tratați numai cu gp100. Au existat 14 decese legate de medicamentele studiate (2,1%), iar 7 au fost asociate cu evenimente adversarial legate de imunitate.

CONCLUZII

Ipilimumab, cu sau fără vaccin peptidic gp100 , comparativ cu gp100 singur, a îmbunătățit supraviețuirea generală la pacienții cu melanom metastatic tratat anterior. Evenimentele adversarial pot fi extreme, de lungă durată sau ambele, dar cele mai multe sunt reversibile cu un tratament adecvat . (Finanțat de Medarex și Bristol-Myers Squibb; numărul ClinicalTrials.gov, NCT00094653.)

srsf

srsf

 

Anti-Guinea pig lymphocytes antibody
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EUR 562
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Description: A Monoclonal antibody against Human CD1a / HTA1 (Mature Langerhans Cells Marker) - With BSA and Azide. The antibodies are raised in Mouse and are from clone O10. This antibody is applicable in WB, IHC and IF, FC, IP, E
Monoclonal CD1a / HTA1 (Mature Langerhans Cells Marker) Antibody - Without BSA and Azide, Clone: O10
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Description: A Monoclonal antibody against Human CD1a / HTA1 (Mature Langerhans Cells Marker) - Without BSA and Azide. The antibodies are raised in Mouse and are from clone O10. This antibody is applicable in IHC-P, IF, FC
Monoclonal CD1a / HTA1 (Mature Langerhans Cells Marker) Antibody - With BSA and Azide, Clone: 66IIC7
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Description: A Monoclonal antibody against Human CD1a / HTA1 (Mature Langerhans Cells Marker) - With BSA and Azide. The antibodies are raised in Mouse and are from clone 66IIC7. This antibody is applicable in IHC, IF, FC
Monoclonal CD1a / HTA1 (Mature Langerhans Cells Marker) Antibody - Without BSA and Azide, Clone: 66IIC7
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EUR 484
Description: A Monoclonal antibody against Human CD1a / HTA1 (Mature Langerhans Cells Marker) - Without BSA and Azide. The antibodies are raised in Mouse and are from clone 66IIC7. This antibody is applicable in IHC, IF, FC
Monoclonal CD1a / HTA1 (Mature Langerhans Cells Marker) Antibody - With BSA and Azide, Clone: CBT6
AMM01445G 0.05mg
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Description: A Monoclonal antibody against Human CD1a / HTA1 (Mature Langerhans Cells Marker) - With BSA and Azide. The antibodies are raised in Mouse and are from clone CBT6. This antibody is applicable in IF, FC
Monoclonal CD1a / HTA1 (Mature Langerhans Cells Marker) Antibody - Without BSA and Azide, Clone: CBT6
AMM01446G 0.1mg
EUR 484
Description: A Monoclonal antibody against Human CD1a / HTA1 (Mature Langerhans Cells Marker) - Without BSA and Azide. The antibodies are raised in Mouse and are from clone CBT6. This antibody is applicable in IF, FC
Monoclonal CD1a (Mature Langerhans Cells Marker) Antibody, Clone: SPM120
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Description: A Monoclonal antibody against Human CD1a (Mature Langerhans Cells Marker). The antibodies are raised in Mouse and are from clone SPM120. This antibody is applicable in IHC, IF, FC
CD1a / HTA1 (Mature Langerhans Cells Marker) (C1A/1506R) Antibody
BNC551506-100 100uL
EUR 199
Description: Primary antibody against CD1a / HTA1 (Mature Langerhans Cells Marker) (C1A/1506R),CF555 conjugate, Concentration: 0.1mg/mL
CD1a / HTA1 (Mature Langerhans Cells Marker) (C1A/1506R) Antibody
BNC551506-500 500uL
EUR 544
Description: Primary antibody against CD1a / HTA1 (Mature Langerhans Cells Marker) (C1A/1506R),CF555 conjugate, Concentration: 0.1mg/mL
CD1a / HTA1 (Mature Langerhans Cells Marker) (rC1A/711) Antibody
BNC551888-100 100uL
EUR 233
Description: Primary antibody against CD1a / HTA1 (Mature Langerhans Cells Marker) (rC1A/711), CF555 conjugate, Concentration: 0.1mg/mL
CD1a / HTA1 (Mature Langerhans Cells Marker) (rC1A/711) Antibody
BNC551888-500 500uL
EUR 545
Description: Primary antibody against CD1a / HTA1 (Mature Langerhans Cells Marker) (rC1A/711), CF555 conjugate, Concentration: 0.1mg/mL
CD1a / HTA1 (Mature Langerhans Cells Marker) (C1A/1506R) Antibody
BNC611506-100 100uL
EUR 199
Description: Primary antibody against CD1a / HTA1 (Mature Langerhans Cells Marker) (C1A/1506R),CF660R conjugate, Concentration: 0.1mg/mL
CD1a / HTA1 (Mature Langerhans Cells Marker) (C1A/1506R) Antibody
BNC611506-500 500uL
EUR 544
Description: Primary antibody against CD1a / HTA1 (Mature Langerhans Cells Marker) (C1A/1506R),CF660R conjugate, Concentration: 0.1mg/mL
CD1a / HTA1 (Mature Langerhans Cells Marker) (rC1A/711) Antibody
BNC611888-100 100uL
EUR 233
Description: Primary antibody against CD1a / HTA1 (Mature Langerhans Cells Marker) (rC1A/711), CF660R conjugate, Concentration: 0.1mg/mL
CD1a / HTA1 (Mature Langerhans Cells Marker) (rC1A/711) Antibody
BNC611888-500 500uL
EUR 545
Description: Primary antibody against CD1a / HTA1 (Mature Langerhans Cells Marker) (rC1A/711), CF660R conjugate, Concentration: 0.1mg/mL
CD1a / HTA1 (Mature Langerhans Cells Marker) (C1A/1506R) Antibody
BNC401506-100 100uL
EUR 199
Description: Primary antibody against CD1a / HTA1 (Mature Langerhans Cells Marker) (C1A/1506R),CF640R conjugate, Concentration: 0.1mg/mL
CD1a / HTA1 (Mature Langerhans Cells Marker) (C1A/1506R) Antibody
BNC401506-500 500uL
EUR 544
Description: Primary antibody against CD1a / HTA1 (Mature Langerhans Cells Marker) (C1A/1506R),CF640R conjugate, Concentration: 0.1mg/mL
CD1a / HTA1 (Mature Langerhans Cells Marker) (rC1A/711) Antibody
BNC401888-100 100uL
EUR 233
Description: Primary antibody against CD1a / HTA1 (Mature Langerhans Cells Marker) (rC1A/711), CF640R conjugate, Concentration: 0.1mg/mL
CD1a / HTA1 (Mature Langerhans Cells Marker) (rC1A/711) Antibody
BNC401888-500 500uL
EUR 545
Description: Primary antibody against CD1a / HTA1 (Mature Langerhans Cells Marker) (rC1A/711), CF640R conjugate, Concentration: 0.1mg/mL
CD1a / HTA1 (Mature Langerhans Cells Marker) (C1A/1506R) Antibody
BNC431506-100 100uL
EUR 199
Description: Primary antibody against CD1a / HTA1 (Mature Langerhans Cells Marker) (C1A/1506R),CF543 conjugate, Concentration: 0.1mg/mL
CD1a / HTA1 (Mature Langerhans Cells Marker) (C1A/1506R) Antibody
BNC431506-500 500uL
EUR 544
Description: Primary antibody against CD1a / HTA1 (Mature Langerhans Cells Marker) (C1A/1506R),CF543 conjugate, Concentration: 0.1mg/mL
CD1a / HTA1 (Mature Langerhans Cells Marker) (rC1A/711) Antibody
BNC431888-100 100uL
EUR 233
Description: Primary antibody against CD1a / HTA1 (Mature Langerhans Cells Marker) (rC1A/711), CF543 conjugate, Concentration: 0.1mg/mL
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BNC431888-500 500uL
EUR 545
Description: Primary antibody against CD1a / HTA1 (Mature Langerhans Cells Marker) (rC1A/711), CF543 conjugate, Concentration: 0.1mg/mL
CD1a / HTA1 (Mature Langerhans Cells Marker) (C1A/1506R) Antibody
BNC471506-100 100uL
EUR 199
Description: Primary antibody against CD1a / HTA1 (Mature Langerhans Cells Marker) (C1A/1506R),CF647 conjugate, Concentration: 0.1mg/mL
CD1a / HTA1 (Mature Langerhans Cells Marker) (C1A/1506R) Antibody
BNC471506-500 500uL
EUR 544
Description: Primary antibody against CD1a / HTA1 (Mature Langerhans Cells Marker) (C1A/1506R),CF647 conjugate, Concentration: 0.1mg/mL
CD1a / HTA1 (Mature Langerhans Cells Marker) (rC1A/711) Antibody
BNC471888-100 100uL
EUR 233
Description: Primary antibody against CD1a / HTA1 (Mature Langerhans Cells Marker) (rC1A/711), CF647 conjugate, Concentration: 0.1mg/mL
CD1a / HTA1 (Mature Langerhans Cells Marker) (rC1A/711) Antibody
BNC471888-500 500uL
EUR 545
Description: Primary antibody against CD1a / HTA1 (Mature Langerhans Cells Marker) (rC1A/711), CF647 conjugate, Concentration: 0.1mg/mL
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EUR 199
Description: Primary antibody against CD1a / HTA1 (Mature Langerhans Cells Marker) (C1A/1506R),CF405M conjugate, Concentration: 0.1mg/mL
CD1a / HTA1 (Mature Langerhans Cells Marker) (C1A/1506R) Antibody
BNC051506-500 500uL
EUR 544
Description: Primary antibody against CD1a / HTA1 (Mature Langerhans Cells Marker) (C1A/1506R),CF405M conjugate, Concentration: 0.1mg/mL
CD1a / HTA1 (Mature Langerhans Cells Marker) (rC1A/711) Antibody
BNC051888-100 100uL
EUR 233
Description: Primary antibody against CD1a / HTA1 (Mature Langerhans Cells Marker) (rC1A/711), CF405M conjugate, Concentration: 0.1mg/mL
CD1a / HTA1 (Mature Langerhans Cells Marker) (rC1A/711) Antibody
BNC051888-500 500uL
EUR 545
Description: Primary antibody against CD1a / HTA1 (Mature Langerhans Cells Marker) (rC1A/711), CF405M conjugate, Concentration: 0.1mg/mL
CD1a / HTA1 (Mature Langerhans Cells Marker) (C1A/1506R) Antibody
BNC041506-100 100uL
EUR 199
Description: Primary antibody against CD1a / HTA1 (Mature Langerhans Cells Marker) (C1A/1506R),CF405S conjugate, Concentration: 0.1mg/mL
CD1a / HTA1 (Mature Langerhans Cells Marker) (C1A/1506R) Antibody
BNC041506-500 500uL
EUR 544
Description: Primary antibody against CD1a / HTA1 (Mature Langerhans Cells Marker) (C1A/1506R),CF405S conjugate, Concentration: 0.1mg/mL
CD1a / HTA1 (Mature Langerhans Cells Marker) (rC1A/711) Antibody
BNC041888-100 100uL
EUR 233
Description: Primary antibody against CD1a / HTA1 (Mature Langerhans Cells Marker) (rC1A/711), CF405S conjugate, Concentration: 0.1mg/mL
CD1a / HTA1 (Mature Langerhans Cells Marker) (rC1A/711) Antibody
BNC041888-500 500uL
EUR 545
Description: Primary antibody against CD1a / HTA1 (Mature Langerhans Cells Marker) (rC1A/711), CF405S conjugate, Concentration: 0.1mg/mL
CD1a / HTA1 (Mature Langerhans Cells Marker) (C1A/1506R) Antibody
BNUB1506-100 100uL
EUR 209
Description: Primary antibody against CD1a / HTA1 (Mature Langerhans Cells Marker) (C1A/1506R), Concentration: 0.2mg/mL
CD1a / HTA1 (Mature Langerhans Cells Marker) (C1A/1506R) Antibody
BNUB1506-500 500uL
EUR 458
Description: Primary antibody against CD1a / HTA1 (Mature Langerhans Cells Marker) (C1A/1506R), Concentration: 0.2mg/mL
CD1a / HTA1 (Mature Langerhans Cells Marker) (rC1A/711) Antibody
BNUB1888-100 100uL
EUR 264
Description: Primary antibody against CD1a / HTA1 (Mature Langerhans Cells Marker) (rC1A/711), Concentration: 0.2mg/mL
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BNUB1888-50 50uL
EUR 405
Description: Primary antibody against CD1a / HTA1 (Mature Langerhans Cells Marker) (rC1A/711), 1mg/mL
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BNUB1888-500 500uL
EUR 513
Description: Primary antibody against CD1a / HTA1 (Mature Langerhans Cells Marker) (rC1A/711), Concentration: 0.2mg/mL
CD1a / HTA1 (Mature Langerhans Cells Marker) (C1A/1506R) Antibody
BNUM1506-50 50uL
EUR 395
Description: Primary antibody against CD1a / HTA1 (Mature Langerhans Cells Marker) (C1A/1506R), 1mg/mL
CD1a / HTA1 (Mature Langerhans Cells Marker) (C1A/1506R) Antibody
BNC681506-100 100uL
EUR 199
Description: Primary antibody against CD1a / HTA1 (Mature Langerhans Cells Marker) (C1A/1506R),CF568 conjugate, Concentration: 0.1mg/mL
CD1a / HTA1 (Mature Langerhans Cells Marker) (C1A/1506R) Antibody
BNC681506-500 500uL
EUR 544
Description: Primary antibody against CD1a / HTA1 (Mature Langerhans Cells Marker) (C1A/1506R),CF568 conjugate, Concentration: 0.1mg/mL
CD1a / HTA1 (Mature Langerhans Cells Marker) (rC1A/711) Antibody
BNC681888-100 100uL
EUR 233
Description: Primary antibody against CD1a / HTA1 (Mature Langerhans Cells Marker) (rC1A/711), CF568 conjugate, Concentration: 0.1mg/mL
CD1a / HTA1 (Mature Langerhans Cells Marker) (rC1A/711) Antibody
BNC681888-500 500uL
EUR 545
Description: Primary antibody against CD1a / HTA1 (Mature Langerhans Cells Marker) (rC1A/711), CF568 conjugate, Concentration: 0.1mg/mL
CD1a / HTA1 (Mature Langerhans Cells Marker) (C1A/1506R) Antibody
BNC701506-100 100uL
EUR 199
Description: Primary antibody against CD1a / HTA1 (Mature Langerhans Cells Marker) (C1A/1506R),CF770 conjugate, Concentration: 0.1mg/mL
CD1a / HTA1 (Mature Langerhans Cells Marker) (C1A/1506R) Antibody
BNC701506-500 500uL
EUR 544
Description: Primary antibody against CD1a / HTA1 (Mature Langerhans Cells Marker) (C1A/1506R),CF770 conjugate, Concentration: 0.1mg/mL
CD1a / HTA1 (Mature Langerhans Cells Marker) (rC1A/711) Antibody
BNC701888-100 100uL
EUR 233
Description: Primary antibody against CD1a / HTA1 (Mature Langerhans Cells Marker) (rC1A/711), CF770 conjugate, Concentration: 0.1mg/mL
CD1a / HTA1 (Mature Langerhans Cells Marker) (rC1A/711) Antibody
BNC701888-500 500uL
EUR 545
Description: Primary antibody against CD1a / HTA1 (Mature Langerhans Cells Marker) (rC1A/711), CF770 conjugate, Concentration: 0.1mg/mL
CD1a / HTA1 (Mature Langerhans Cells Marker) (C1A/1506R) Antibody
BNC881506-100 100uL
EUR 199
Description: Primary antibody against CD1a / HTA1 (Mature Langerhans Cells Marker) (C1A/1506R),CF488A conjugate, Concentration: 0.1mg/mL
CD1a / HTA1 (Mature Langerhans Cells Marker) (C1A/1506R) Antibody
BNC881506-500 500uL
EUR 544
Description: Primary antibody against CD1a / HTA1 (Mature Langerhans Cells Marker) (C1A/1506R),CF488A conjugate, Concentration: 0.1mg/mL
CD1a / HTA1 (Mature Langerhans Cells Marker) (rC1A/711) Antibody
BNC881888-100 100uL
EUR 233
Description: Primary antibody against CD1a / HTA1 (Mature Langerhans Cells Marker) (rC1A/711), CF488A conjugate, Concentration: 0.1mg/mL
CD1a / HTA1 (Mature Langerhans Cells Marker) (rC1A/711) Antibody
BNC881888-500 500uL
EUR 545
Description: Primary antibody against CD1a / HTA1 (Mature Langerhans Cells Marker) (rC1A/711), CF488A conjugate, Concentration: 0.1mg/mL
CD1a / HTA1 (Mature Langerhans Cells Marker) (C1A/1506R) Antibody
BNC941506-100 100uL
EUR 199
Description: Primary antibody against CD1a / HTA1 (Mature Langerhans Cells Marker) (C1A/1506R),CF594 conjugate, Concentration: 0.1mg/mL
CD1a / HTA1 (Mature Langerhans Cells Marker) (C1A/1506R) Antibody
BNC941506-500 500uL
EUR 544
Description: Primary antibody against CD1a / HTA1 (Mature Langerhans Cells Marker) (C1A/1506R),CF594 conjugate, Concentration: 0.1mg/mL
CD1a / HTA1 (Mature Langerhans Cells Marker) (rC1A/711) Antibody
BNC941888-100 100uL
EUR 233
Description: Primary antibody against CD1a / HTA1 (Mature Langerhans Cells Marker) (rC1A/711), CF594 conjugate, Concentration: 0.1mg/mL
CD1a / HTA1 (Mature Langerhans Cells Marker) (rC1A/711) Antibody
BNC941888-500 500uL
EUR 545
Description: Primary antibody against CD1a / HTA1 (Mature Langerhans Cells Marker) (rC1A/711), CF594 conjugate, Concentration: 0.1mg/mL
CD1a / HTA1 (Mature Langerhans Cells Marker) (C1A/1506R) Antibody
BNCB1506-100 100uL
EUR 199
Description: Primary antibody against CD1a / HTA1 (Mature Langerhans Cells Marker) (C1A/1506R),Biotin conjugate, Concentration: 0.1mg/mL
CD1a / HTA1 (Mature Langerhans Cells Marker) (C1A/1506R) Antibody
BNCB1506-500 500uL
EUR 544
Description: Primary antibody against CD1a / HTA1 (Mature Langerhans Cells Marker) (C1A/1506R),Biotin conjugate, Concentration: 0.1mg/mL
CD1a / HTA1 (Mature Langerhans Cells Marker) (rC1A/711) Antibody
BNCB1888-100 100uL
EUR 233
Description: Primary antibody against CD1a / HTA1 (Mature Langerhans Cells Marker) (rC1A/711), Biotin conjugate, Concentration: 0.1mg/mL
CD1a / HTA1 (Mature Langerhans Cells Marker) (rC1A/711) Antibody
BNCB1888-500 500uL
EUR 545
Description: Primary antibody against CD1a / HTA1 (Mature Langerhans Cells Marker) (rC1A/711), Biotin conjugate, Concentration: 0.1mg/mL
CD1a / HTA1 (Mature Langerhans Cells Marker) (C1A/1506R) Antibody
BNCH1506-100 100uL
EUR 199
Description: Primary antibody against CD1a / HTA1 (Mature Langerhans Cells Marker) (C1A/1506R),Horseradish Peroxidase conjugate, Concentration: 0.1mg/mL
CD1a / HTA1 (Mature Langerhans Cells Marker) (C1A/1506R) Antibody
BNCH1506-500 500uL
EUR 544
Description: Primary antibody against CD1a / HTA1 (Mature Langerhans Cells Marker) (C1A/1506R),Horseradish Peroxidase conjugate, Concentration: 0.1mg/mL
CD1a / HTA1 (Mature Langerhans Cells Marker) (rC1A/711) Antibody
BNCH1888-100 100uL
EUR 233
Description: Primary antibody against CD1a / HTA1 (Mature Langerhans Cells Marker) (rC1A/711), Horseradish Peroxidase conjugate, Concentration: 0.1mg/mL
CD1a / HTA1 (Mature Langerhans Cells Marker) (rC1A/711) Antibody
BNCH1888-500 500uL
EUR 545
Description: Primary antibody against CD1a / HTA1 (Mature Langerhans Cells Marker) (rC1A/711), Horseradish Peroxidase conjugate, Concentration: 0.1mg/mL
CD1a / HTA1 (Mature Langerhans Cells Marker) (C1A/1506R) Antibody
BNC801506-100 100uL
EUR 199
Description: Primary antibody against CD1a / HTA1 (Mature Langerhans Cells Marker) (C1A/1506R),CF680 conjugate, Concentration: 0.1mg/mL
CD1a / HTA1 (Mature Langerhans Cells Marker) (C1A/1506R) Antibody
BNC801506-500 500uL
EUR 544
Description: Primary antibody against CD1a / HTA1 (Mature Langerhans Cells Marker) (C1A/1506R),CF680 conjugate, Concentration: 0.1mg/mL
CD1a / HTA1 (Mature Langerhans Cells Marker) (rC1A/711) Antibody
BNC801888-100 100uL
EUR 233
Description: Primary antibody against CD1a / HTA1 (Mature Langerhans Cells Marker) (rC1A/711), CF680 conjugate, Concentration: 0.1mg/mL
CD1a / HTA1 (Mature Langerhans Cells Marker) (rC1A/711) Antibody
BNC801888-500 500uL
EUR 545
Description: Primary antibody against CD1a / HTA1 (Mature Langerhans Cells Marker) (rC1A/711), CF680 conjugate, Concentration: 0.1mg/mL
CD1a / HTA1 (Mature Langerhans Cells Marker) (C1A/1506R) Antibody
BNCP1506-250 250uL
EUR 383
Description: Primary antibody against CD1a / HTA1 (Mature Langerhans Cells Marker) (C1A/1506R),PerCP conjugate, Concentration: 0.1mg/mL
CD1a / HTA1 (Mature Langerhans Cells Marker) (rC1A/711) Antibody
BNCP1888-250 250uL
EUR 394
Description: Primary antibody against CD1a / HTA1 (Mature Langerhans Cells Marker) (rC1A/711), PerCP conjugate, Concentration: 0.1mg/mL
CD1a / HTA1 (Mature Langerhans Cells Marker) (C1A/1506R) Antibody
BNCR1506-250 250uL
EUR 383
Description: Primary antibody against CD1a / HTA1 (Mature Langerhans Cells Marker) (C1A/1506R),RPE conjugate, Concentration: 0.1mg/mL
CD1a / HTA1 (Mature Langerhans Cells Marker) (rC1A/711) Antibody
BNCR1888-250 250uL
EUR 394
Description: Primary antibody against CD1a / HTA1 (Mature Langerhans Cells Marker) (rC1A/711), RPE conjugate, Concentration: 0.1mg/mL
CD1a / HTA1 (Mature Langerhans Cells Marker) (C1A/1506R) Antibody
BNCA1506-250 250uL
EUR 383
Description: Primary antibody against CD1a / HTA1 (Mature Langerhans Cells Marker) (C1A/1506R),APC conjugate, Concentration: 0.1mg/mL
CD1a / HTA1 (Mature Langerhans Cells Marker) (rC1A/711) Antibody
BNCA1888-250 250uL
EUR 394
Description: Primary antibody against CD1a / HTA1 (Mature Langerhans Cells Marker) (rC1A/711), APC conjugate, Concentration: 0.1mg/mL
CD1a / HTA1 (Mature Langerhans Cells Marker) (C1A/1506R) Antibody
BNCAP1506-100 100uL
EUR 199
Description: Primary antibody against CD1a / HTA1 (Mature Langerhans Cells Marker) (C1A/1506R),Alkaline Phosphatase conjugate, Concentration: 0.1mg/mL
CD1a / HTA1 (Mature Langerhans Cells Marker) (C1A/1506R) Antibody
BNCAP1506-500 500uL
EUR 544
Description: Primary antibody against CD1a / HTA1 (Mature Langerhans Cells Marker) (C1A/1506R),Alkaline Phosphatase conjugate, Concentration: 0.1mg/mL
CD1a / HTA1 (Mature Langerhans Cells Marker) (rC1A/711) Antibody
BNCAP1888-100 100uL
EUR 233
Description: Primary antibody against CD1a / HTA1 (Mature Langerhans Cells Marker) (rC1A/711), Alkaline Phosphatase conjugate, Concentration: 0.1mg/mL
CD1a / HTA1 (Mature Langerhans Cells Marker) (rC1A/711) Antibody
BNCAP1888-500 500uL
EUR 545
Description: Primary antibody against CD1a / HTA1 (Mature Langerhans Cells Marker) (rC1A/711), Alkaline Phosphatase conjugate, Concentration: 0.1mg/mL
CD1a / HTA1 (Mature Langerhans Cells Marker) (C1A/1506R) Antibody
BNC811506-100 100uL
EUR 199
Description: Primary antibody against CD1a / HTA1 (Mature Langerhans Cells Marker) (C1A/1506R),CF680R conjugate, Concentration: 0.1mg/mL
CD1a / HTA1 (Mature Langerhans Cells Marker) (C1A/1506R) Antibody
BNC811506-500 500uL
EUR 544
Description: Primary antibody against CD1a / HTA1 (Mature Langerhans Cells Marker) (C1A/1506R),CF680R conjugate, Concentration: 0.1mg/mL
CD1a / HTA1 (Mature Langerhans Cells Marker) (rC1A/711) Antibody
BNC811888-100 100uL
EUR 233
Description: Primary antibody against CD1a / HTA1 (Mature Langerhans Cells Marker) (rC1A/711), CF680R conjugate, Concentration: 0.1mg/mL
CD1a / HTA1 (Mature Langerhans Cells Marker) (rC1A/711) Antibody
BNC811888-500 500uL
EUR 545
Description: Primary antibody against CD1a / HTA1 (Mature Langerhans Cells Marker) (rC1A/711), CF680R conjugate, Concentration: 0.1mg/mL
Anti-CD1a / HTA1 (Mature Langerhans Cells Marker) Monoclonal Antibody
M00375 100ug/vial
EUR 397
Description: Mouse Monoclonal CD1a / HTA1 (Mature Langerhans Cells Marker) Antibody. Validated in IHC and tested in Human.
T-Lymphocytes Antibody (APC)
abx415483-100tests 100 tests
EUR 829
  • Shipped within 1 week.
T-Lymphocytes Antibody (FITC)
abx415484-100tests 100 tests
EUR 648
  • Shipped within 1 week.
T-Lymphocytes Antibody (FITC)
abx415542-100tests 100 tests
EUR 648
  • Shipped within 1 week.
Monoclonal CD1a / HTA1 (Mature Langerhans Cells Marker) Antibody - With BSA and Azide, Clone: C1A/711
AMM00073G 0.05mg
EUR 396
Description: A Monoclonal antibody against Human CD1a / HTA1 (Mature Langerhans Cells Marker) - With BSA and Azide. The antibodies are raised in Mouse and are from clone C1A/711. This antibody is applicable in WB, IHC and IF, FC, IP, E
Monoclonal CD1a / HTA1 (Mature Langerhans Cells Marker) Antibody - Without BSA and Azide, Clone: C1A/711
AMM00441G 0.1mg
EUR 484
Description: A Monoclonal antibody against Human CD1a / HTA1 (Mature Langerhans Cells Marker) - Without BSA and Azide. The antibodies are raised in Mouse and are from clone C1A/711. This antibody is applicable in IHC-P, IF, FC
Monoclonal CD1a / HTA1 (Mature Langerhans Cells Marker) Antibody, Clone: O10
AMM01439G 7 ml
EUR 484
Description: A Monoclonal antibody against Human CD1a / HTA1 (Mature Langerhans Cells Marker). The antibodies are raised in Mouse and are from clone O10. This antibody is applicable in IHC, IF, FC

Blokada immunologicznych punktów kontrolnych w immunoterapii raka.

Printre cele mai promițătoare abordări ale activării imunității terapeutice antitumorale se numără blocada punctelor de management imune. Punctele de management imune se referă la o mulțime de căi inhibitorii conectate la sistemul imunitar care sunt cruciale pentru menținerea autotoleranței și modularea duratei și amplitudinii răspunsurilor imune fiziologice în țesuturile periferice, în scopul de a minimiza deteriorarea colaterală a țesuturilor. Acum este clar că tumorile cooptează anumite căi ale punctelor de management imunitar ca un mecanism main de rezistență imună, în particular împotriva celulelor T   care sunt specifice antigenelor tumorale.

Deoarece multe dintre punctele de management imune sunt inițiate de interacțiunile ligand-receptor , ele pot fi ușor blocate de anticorpi sau modulate de forme recombinate de liganzi sau receptori. Anticorpii citotoxici ai antigenului four asociat cu limfocitele T (CTLA4) au fost primii din această clasă de imunoterapii care au obținut aprobarea Administrației SUA pentru Alimente și Medicamente (FDA). Descoperirile clinice preliminare cu blocante ale proteinelor suplimentare ale punctului de management imun, cum ar fi  proteina programată  1 a morții celulare (PD1), indică oportunități largi și numerous de a spori imunitatea antitumorală cu potențialul de a produce răspunsuri clinice durabile.

Kontrola rozwoju limfocytów T regulatorowych przez czynnik transkrypcyjny Foxp3.

 

Celulele T de reglementare   se angajează în menținerea autotoleranței imunologice prin suprimarea activă a limfocitelor auto-reactive  . Cu toate acestea, se știe puțin despre mecanismul molecular al dezvoltării lor. Aici arătăm că Foxp3, care codifică un issue de transcripție care este genetic defect într-un sindrom autoimun și inflamator la oameni și șoareci, este exprimat în mod particular în celulele T reglatoare CD4 + care apar în mod pure  . In plus, transferul de gene retrovirale de Foxp3 convertește T naive  celule  spre un T de reglementare  de celule  fenotip comparable cu cel al produsului pure T reglatoare CD4 +  celule . Astfel, Foxp3 este o genă reglatoare cheie pentru dezvoltarea reglatorului T celule .

Przewlekłe zapalenie tłuszczu odgrywa kluczową rolę w rozwoju insulinooporności związanej z otyłością.

 

Rezistența la insulină apare din incapacitatea insulinei de a acționa regular în reglarea metabolismului nutrienților în țesuturile periferice. Dovezi în creștere din studiile populației umane și cercetările pe animale au stabilit corelații, precum și legături cauzale între inflamația cronică și rezistența la insulină. Cu toate acestea, căile moleculare de bază sunt în mare parte necunoscute. În acest raport, arătăm că multe inflamații și gene specifice macrofagelor sunt reglate în mod dramatic în sus în țesutul adipos alb (WAT) în modele de șoarece de obezitate genetică și bogată în grăsimi indusă de dietă (DIO).

Reglarea ascendentă este crescută progresiv în WAT la șoareci cu DIO și precede o creștere dramatică a nivelului de insulină circulantă. După tratamentul cu rosiglitazonă, un medicament sensibilizant la insulină, aceste gene originate de macrofage sunt reglate în jos. Histologic, există dovezi de infiltrare semnificativă a macrofagelor, dar nu neutrofile și  limfocite , în WAT șoarecilor obezi, cu semne de lipoliza adipocitelor și formarea de gigant multinucleate  celule. Aceste date sugerează că macrofagele din WAT joacă un rol activ în obezitatea morbidă și că activitățile inflamatorii legate de macrofage pot contribui la patogeneza rezistenței la insulină indusă de obezitate. Propunem că rezistența la insulină legată de obezitate este, cel puțin parțial, o boală inflamatorie cronică inițiată în țesutul adipos.

Dwa podzbiory limfocytów T pamięci o różnych potencjałach naprowadzania i funkcjach efektorowych.

Limfocitele T naive   călătoresc în  zonele celulelor T ale organelor limfoide secundare în căutarea antigenului prezentat de celulele dendritice  . Odată activate, acestea proliferează viguros, generând celule efectoare   care pot migra către  zonele celulelor B sau către țesuturile inflamate. O fracțiune din limfocitele T amorsate   persistă ca celule de memorie circulante   care pot conferi protecție și pot da, la provocarea secundară, un răspuns calitativ diferit și îmbunătățit cantitativ. Natura  celulelor  care mediază diferitele fațete ale memoriei imunologice rămâne nerezolvată.

Aici arătăm că expresia CCR7, un receptor de chemokine care controlează aderarea la organele limfoide secundare, împarte celulele T de memorie umană   în două subseturi funcționale distincte. CCR7 – celulele de memorie   exprimă receptori pentru migrația către țesuturile inflamate și prezintă funcția efectoare imediate. În schimb, celulele de memorie CCR7 +   exprimă receptori de  aderare  la ganglionii limfatici și nu au funcție efectoare imediate, dar stimulează eficient celulele dendritice  și se diferențiază în celule efectoare CCR7  după stimulare secundară. Celulele CCR7 + și CCR7-T  , pe care le-am numit memorie centrală (TCM) și memorie efectoare (TEM), se diferențiază în mod pas cu pas de celulele T naive , persistă ani de zile după imunizare și allow o diviziune a muncii în răspunsul de memorie.

 

T-Lymphocytes Antibody

abx415543-01mg 0.1 mg
EUR 453
  • Shipped within 1 week.

Monoclonal CD1a (Mature Langerhans Cells Marker) Antibody, Clone: SPM120

AMM01440G 7 ml
EUR 484
Description: A Monoclonal antibody against Human CD1a (Mature Langerhans Cells Marker). The antibodies are raised in Mouse and are from clone SPM120. This antibody is applicable in IHC, IF, FC

CD1a / HTA1 (Mature Langerhans Cells Marker) (C1A/1506R) Antibody

BNC551506-100 100uL
EUR 199
Description: Primary antibody against CD1a / HTA1 (Mature Langerhans Cells Marker) (C1A/1506R),CF555 conjugate, Concentration: 0.1mg/mL

CD1a / HTA1 (Mature Langerhans Cells Marker) (C1A/1506R) Antibody

BNC551506-500 500uL
EUR 544
Description: Primary antibody against CD1a / HTA1 (Mature Langerhans Cells Marker) (C1A/1506R),CF555 conjugate, Concentration: 0.1mg/mL

CD1a / HTA1 (Mature Langerhans Cells Marker) (rC1A/711) Antibody

BNC551888-100 100uL
EUR 233
Description: Primary antibody against CD1a / HTA1 (Mature Langerhans Cells Marker) (rC1A/711), CF555 conjugate, Concentration: 0.1mg/mL

CD1a / HTA1 (Mature Langerhans Cells Marker) (rC1A/711) Antibody

BNC551888-500 500uL
EUR 545
Description: Primary antibody against CD1a / HTA1 (Mature Langerhans Cells Marker) (rC1A/711), CF555 conjugate, Concentration: 0.1mg/mL

CD1a / HTA1 (Mature Langerhans Cells Marker) (C1A/1506R) Antibody

BNC611506-100 100uL
EUR 199
Description: Primary antibody against CD1a / HTA1 (Mature Langerhans Cells Marker) (C1A/1506R),CF660R conjugate, Concentration: 0.1mg/mL

CD1a / HTA1 (Mature Langerhans Cells Marker) (C1A/1506R) Antibody

BNC611506-500 500uL
EUR 544
Description: Primary antibody against CD1a / HTA1 (Mature Langerhans Cells Marker) (C1A/1506R),CF660R conjugate, Concentration: 0.1mg/mL

CD1a / HTA1 (Mature Langerhans Cells Marker) (rC1A/711) Antibody

BNC611888-100 100uL
EUR 233
Description: Primary antibody against CD1a / HTA1 (Mature Langerhans Cells Marker) (rC1A/711), CF660R conjugate, Concentration: 0.1mg/mL

CD1a / HTA1 (Mature Langerhans Cells Marker) (rC1A/711) Antibody

BNC611888-500 500uL
EUR 545
Description: Primary antibody against CD1a / HTA1 (Mature Langerhans Cells Marker) (rC1A/711), CF660R conjugate, Concentration: 0.1mg/mL

CD1a / HTA1 (Mature Langerhans Cells Marker) (C1A/1506R) Antibody

BNC401506-100 100uL
EUR 199
Description: Primary antibody against CD1a / HTA1 (Mature Langerhans Cells Marker) (C1A/1506R),CF640R conjugate, Concentration: 0.1mg/mL

CD1a / HTA1 (Mature Langerhans Cells Marker) (C1A/1506R) Antibody

BNC401506-500 500uL
EUR 544
Description: Primary antibody against CD1a / HTA1 (Mature Langerhans Cells Marker) (C1A/1506R),CF640R conjugate, Concentration: 0.1mg/mL

CD1a / HTA1 (Mature Langerhans Cells Marker) (rC1A/711) Antibody

BNC401888-100 100uL
EUR 233
Description: Primary antibody against CD1a / HTA1 (Mature Langerhans Cells Marker) (rC1A/711), CF640R conjugate, Concentration: 0.1mg/mL

CD1a / HTA1 (Mature Langerhans Cells Marker) (rC1A/711) Antibody

BNC401888-500 500uL
EUR 545
Description: Primary antibody against CD1a / HTA1 (Mature Langerhans Cells Marker) (rC1A/711), CF640R conjugate, Concentration: 0.1mg/mL

CD1a / HTA1 (Mature Langerhans Cells Marker) (C1A/1506R) Antibody

BNC431506-100 100uL
EUR 199
Description: Primary antibody against CD1a / HTA1 (Mature Langerhans Cells Marker) (C1A/1506R),CF543 conjugate, Concentration: 0.1mg/mL

CD1a / HTA1 (Mature Langerhans Cells Marker) (C1A/1506R) Antibody

BNC431506-500 500uL
EUR 544
Description: Primary antibody against CD1a / HTA1 (Mature Langerhans Cells Marker) (C1A/1506R),CF543 conjugate, Concentration: 0.1mg/mL

CD1a / HTA1 (Mature Langerhans Cells Marker) (rC1A/711) Antibody

BNC431888-100 100uL
EUR 233
Description: Primary antibody against CD1a / HTA1 (Mature Langerhans Cells Marker) (rC1A/711), CF543 conjugate, Concentration: 0.1mg/mL

CD1a / HTA1 (Mature Langerhans Cells Marker) (rC1A/711) Antibody

BNC431888-500 500uL
EUR 545
Description: Primary antibody against CD1a / HTA1 (Mature Langerhans Cells Marker) (rC1A/711), CF543 conjugate, Concentration: 0.1mg/mL

CD1a / HTA1 (Mature Langerhans Cells Marker) (C1A/1506R) Antibody

BNC471506-100 100uL
EUR 199
Description: Primary antibody against CD1a / HTA1 (Mature Langerhans Cells Marker) (C1A/1506R),CF647 conjugate, Concentration: 0.1mg/mL

CD1a / HTA1 (Mature Langerhans Cells Marker) (C1A/1506R) Antibody

BNC471506-500 500uL
EUR 544
Description: Primary antibody against CD1a / HTA1 (Mature Langerhans Cells Marker) (C1A/1506R),CF647 conjugate, Concentration: 0.1mg/mL

CD1a / HTA1 (Mature Langerhans Cells Marker) (rC1A/711) Antibody

BNC471888-100 100uL
EUR 233
Description: Primary antibody against CD1a / HTA1 (Mature Langerhans Cells Marker) (rC1A/711), CF647 conjugate, Concentration: 0.1mg/mL

CD1a / HTA1 (Mature Langerhans Cells Marker) (rC1A/711) Antibody

BNC471888-500 500uL
EUR 545
Description: Primary antibody against CD1a / HTA1 (Mature Langerhans Cells Marker) (rC1A/711), CF647 conjugate, Concentration: 0.1mg/mL

CD1a / HTA1 (Mature Langerhans Cells Marker) (C1A/1506R) Antibody

BNC051506-100 100uL
EUR 199
Description: Primary antibody against CD1a / HTA1 (Mature Langerhans Cells Marker) (C1A/1506R),CF405M conjugate, Concentration: 0.1mg/mL

CD1a / HTA1 (Mature Langerhans Cells Marker) (C1A/1506R) Antibody

BNC051506-500 500uL
EUR 544
Description: Primary antibody against CD1a / HTA1 (Mature Langerhans Cells Marker) (C1A/1506R),CF405M conjugate, Concentration: 0.1mg/mL

CD1a / HTA1 (Mature Langerhans Cells Marker) (rC1A/711) Antibody

BNC051888-100 100uL
EUR 233
Description: Primary antibody against CD1a / HTA1 (Mature Langerhans Cells Marker) (rC1A/711), CF405M conjugate, Concentration: 0.1mg/mL

CD1a / HTA1 (Mature Langerhans Cells Marker) (rC1A/711) Antibody

BNC051888-500 500uL
EUR 545
Description: Primary antibody against CD1a / HTA1 (Mature Langerhans Cells Marker) (rC1A/711), CF405M conjugate, Concentration: 0.1mg/mL

CD1a / HTA1 (Mature Langerhans Cells Marker) (C1A/1506R) Antibody

BNC041506-100 100uL
EUR 199
Description: Primary antibody against CD1a / HTA1 (Mature Langerhans Cells Marker) (C1A/1506R),CF405S conjugate, Concentration: 0.1mg/mL

CD1a / HTA1 (Mature Langerhans Cells Marker) (C1A/1506R) Antibody

BNC041506-500 500uL
EUR 544
Description: Primary antibody against CD1a / HTA1 (Mature Langerhans Cells Marker) (C1A/1506R),CF405S conjugate, Concentration: 0.1mg/mL

CD1a / HTA1 (Mature Langerhans Cells Marker) (rC1A/711) Antibody

BNC041888-100 100uL
EUR 233
Description: Primary antibody against CD1a / HTA1 (Mature Langerhans Cells Marker) (rC1A/711), CF405S conjugate, Concentration: 0.1mg/mL

CD1a / HTA1 (Mature Langerhans Cells Marker) (rC1A/711) Antibody

BNC041888-500 500uL
EUR 545
Description: Primary antibody against CD1a / HTA1 (Mature Langerhans Cells Marker) (rC1A/711), CF405S conjugate, Concentration: 0.1mg/mL

CD1a / HTA1 (Mature Langerhans Cells Marker) (C1A/1506R) Antibody

BNUB1506-100 100uL
EUR 209
Description: Primary antibody against CD1a / HTA1 (Mature Langerhans Cells Marker) (C1A/1506R), Concentration: 0.2mg/mL

CD1a / HTA1 (Mature Langerhans Cells Marker) (C1A/1506R) Antibody

BNUB1506-500 500uL
EUR 458
Description: Primary antibody against CD1a / HTA1 (Mature Langerhans Cells Marker) (C1A/1506R), Concentration: 0.2mg/mL

CD1a / HTA1 (Mature Langerhans Cells Marker) (rC1A/711) Antibody

BNUB1888-100 100uL
EUR 264
Description: Primary antibody against CD1a / HTA1 (Mature Langerhans Cells Marker) (rC1A/711), Concentration: 0.2mg/mL

CD1a / HTA1 (Mature Langerhans Cells Marker) (rC1A/711) Antibody

BNUB1888-50 50uL
EUR 405
Description: Primary antibody against CD1a / HTA1 (Mature Langerhans Cells Marker) (rC1A/711), 1mg/mL

CD1a / HTA1 (Mature Langerhans Cells Marker) (rC1A/711) Antibody

BNUB1888-500 500uL
EUR 513
Description: Primary antibody against CD1a / HTA1 (Mature Langerhans Cells Marker) (rC1A/711), Concentration: 0.2mg/mL

CD1a / HTA1 (Mature Langerhans Cells Marker) (C1A/1506R) Antibody

BNUM1506-50 50uL
EUR 395
Description: Primary antibody against CD1a / HTA1 (Mature Langerhans Cells Marker) (C1A/1506R), 1mg/mL

CD1a / HTA1 (Mature Langerhans Cells Marker) (C1A/1506R) Antibody

BNC681506-100 100uL
EUR 199
Description: Primary antibody against CD1a / HTA1 (Mature Langerhans Cells Marker) (C1A/1506R),CF568 conjugate, Concentration: 0.1mg/mL

CD1a / HTA1 (Mature Langerhans Cells Marker) (C1A/1506R) Antibody

BNC681506-500 500uL
EUR 544
Description: Primary antibody against CD1a / HTA1 (Mature Langerhans Cells Marker) (C1A/1506R),CF568 conjugate, Concentration: 0.1mg/mL

CD1a / HTA1 (Mature Langerhans Cells Marker) (rC1A/711) Antibody

BNC681888-100 100uL
EUR 233
Description: Primary antibody against CD1a / HTA1 (Mature Langerhans Cells Marker) (rC1A/711), CF568 conjugate, Concentration: 0.1mg/mL

CD1a / HTA1 (Mature Langerhans Cells Marker) (rC1A/711) Antibody

BNC681888-500 500uL
EUR 545
Description: Primary antibody against CD1a / HTA1 (Mature Langerhans Cells Marker) (rC1A/711), CF568 conjugate, Concentration: 0.1mg/mL

CD1a / HTA1 (Mature Langerhans Cells Marker) (C1A/1506R) Antibody

BNC701506-100 100uL
EUR 199
Description: Primary antibody against CD1a / HTA1 (Mature Langerhans Cells Marker) (C1A/1506R),CF770 conjugate, Concentration: 0.1mg/mL

CD1a / HTA1 (Mature Langerhans Cells Marker) (C1A/1506R) Antibody

BNC701506-500 500uL
EUR 544
Description: Primary antibody against CD1a / HTA1 (Mature Langerhans Cells Marker) (C1A/1506R),CF770 conjugate, Concentration: 0.1mg/mL

CD1a / HTA1 (Mature Langerhans Cells Marker) (rC1A/711) Antibody

BNC701888-100 100uL
EUR 233
Description: Primary antibody against CD1a / HTA1 (Mature Langerhans Cells Marker) (rC1A/711), CF770 conjugate, Concentration: 0.1mg/mL

CD1a / HTA1 (Mature Langerhans Cells Marker) (rC1A/711) Antibody

BNC701888-500 500uL
EUR 545
Description: Primary antibody against CD1a / HTA1 (Mature Langerhans Cells Marker) (rC1A/711), CF770 conjugate, Concentration: 0.1mg/mL

CD1a / HTA1 (Mature Langerhans Cells Marker) (C1A/1506R) Antibody

BNC881506-100 100uL
EUR 199
Description: Primary antibody against CD1a / HTA1 (Mature Langerhans Cells Marker) (C1A/1506R),CF488A conjugate, Concentration: 0.1mg/mL

CD1a / HTA1 (Mature Langerhans Cells Marker) (C1A/1506R) Antibody

BNC881506-500 500uL
EUR 544
Description: Primary antibody against CD1a / HTA1 (Mature Langerhans Cells Marker) (C1A/1506R),CF488A conjugate, Concentration: 0.1mg/mL

CD1a / HTA1 (Mature Langerhans Cells Marker) (rC1A/711) Antibody

BNC881888-100 100uL
EUR 233
Description: Primary antibody against CD1a / HTA1 (Mature Langerhans Cells Marker) (rC1A/711), CF488A conjugate, Concentration: 0.1mg/mL

CD1a / HTA1 (Mature Langerhans Cells Marker) (rC1A/711) Antibody

BNC881888-500 500uL
EUR 545
Description: Primary antibody against CD1a / HTA1 (Mature Langerhans Cells Marker) (rC1A/711), CF488A conjugate, Concentration: 0.1mg/mL

CD1a / HTA1 (Mature Langerhans Cells Marker) (C1A/1506R) Antibody

BNC941506-100 100uL
EUR 199
Description: Primary antibody against CD1a / HTA1 (Mature Langerhans Cells Marker) (C1A/1506R),CF594 conjugate, Concentration: 0.1mg/mL

CD1a / HTA1 (Mature Langerhans Cells Marker) (C1A/1506R) Antibody

BNC941506-500 500uL
EUR 544
Description: Primary antibody against CD1a / HTA1 (Mature Langerhans Cells Marker) (C1A/1506R),CF594 conjugate, Concentration: 0.1mg/mL

CD1a / HTA1 (Mature Langerhans Cells Marker) (rC1A/711) Antibody

BNC941888-100 100uL
EUR 233
Description: Primary antibody against CD1a / HTA1 (Mature Langerhans Cells Marker) (rC1A/711), CF594 conjugate, Concentration: 0.1mg/mL

CD1a / HTA1 (Mature Langerhans Cells Marker) (rC1A/711) Antibody

BNC941888-500 500uL
EUR 545
Description: Primary antibody against CD1a / HTA1 (Mature Langerhans Cells Marker) (rC1A/711), CF594 conjugate, Concentration: 0.1mg/mL

CD1a / HTA1 (Mature Langerhans Cells Marker) (C1A/1506R) Antibody

BNCB1506-100 100uL
EUR 199
Description: Primary antibody against CD1a / HTA1 (Mature Langerhans Cells Marker) (C1A/1506R),Biotin conjugate, Concentration: 0.1mg/mL

CD1a / HTA1 (Mature Langerhans Cells Marker) (C1A/1506R) Antibody

BNCB1506-500 500uL
EUR 544
Description: Primary antibody against CD1a / HTA1 (Mature Langerhans Cells Marker) (C1A/1506R),Biotin conjugate, Concentration: 0.1mg/mL

CD1a / HTA1 (Mature Langerhans Cells Marker) (rC1A/711) Antibody

BNCB1888-100 100uL
EUR 233
Description: Primary antibody against CD1a / HTA1 (Mature Langerhans Cells Marker) (rC1A/711), Biotin conjugate, Concentration: 0.1mg/mL

CD1a / HTA1 (Mature Langerhans Cells Marker) (rC1A/711) Antibody

BNCB1888-500 500uL
EUR 545
Description: Primary antibody against CD1a / HTA1 (Mature Langerhans Cells Marker) (rC1A/711), Biotin conjugate, Concentration: 0.1mg/mL

CD1a / HTA1 (Mature Langerhans Cells Marker) (C1A/1506R) Antibody

BNCH1506-100 100uL
EUR 199
Description: Primary antibody against CD1a / HTA1 (Mature Langerhans Cells Marker) (C1A/1506R),Horseradish Peroxidase conjugate, Concentration: 0.1mg/mL

CD1a / HTA1 (Mature Langerhans Cells Marker) (C1A/1506R) Antibody

BNCH1506-500 500uL
EUR 544
Description: Primary antibody against CD1a / HTA1 (Mature Langerhans Cells Marker) (C1A/1506R),Horseradish Peroxidase conjugate, Concentration: 0.1mg/mL

CD1a / HTA1 (Mature Langerhans Cells Marker) (rC1A/711) Antibody

BNCH1888-100 100uL
EUR 233
Description: Primary antibody against CD1a / HTA1 (Mature Langerhans Cells Marker) (rC1A/711), Horseradish Peroxidase conjugate, Concentration: 0.1mg/mL

CD1a / HTA1 (Mature Langerhans Cells Marker) (rC1A/711) Antibody

BNCH1888-500 500uL
EUR 545
Description: Primary antibody against CD1a / HTA1 (Mature Langerhans Cells Marker) (rC1A/711), Horseradish Peroxidase conjugate, Concentration: 0.1mg/mL

CD1a / HTA1 (Mature Langerhans Cells Marker) (C1A/1506R) Antibody

BNC801506-100 100uL
EUR 199
Description: Primary antibody against CD1a / HTA1 (Mature Langerhans Cells Marker) (C1A/1506R),CF680 conjugate, Concentration: 0.1mg/mL

CD1a / HTA1 (Mature Langerhans Cells Marker) (C1A/1506R) Antibody

BNC801506-500 500uL
EUR 544
Description: Primary antibody against CD1a / HTA1 (Mature Langerhans Cells Marker) (C1A/1506R),CF680 conjugate, Concentration: 0.1mg/mL

CD1a / HTA1 (Mature Langerhans Cells Marker) (rC1A/711) Antibody

BNC801888-100 100uL
EUR 233
Description: Primary antibody against CD1a / HTA1 (Mature Langerhans Cells Marker) (rC1A/711), CF680 conjugate, Concentration: 0.1mg/mL

CD1a / HTA1 (Mature Langerhans Cells Marker) (rC1A/711) Antibody

BNC801888-500 500uL
EUR 545
Description: Primary antibody against CD1a / HTA1 (Mature Langerhans Cells Marker) (rC1A/711), CF680 conjugate, Concentration: 0.1mg/mL

CD1a / HTA1 (Mature Langerhans Cells Marker) (C1A/1506R) Antibody

BNCP1506-250 250uL
EUR 383
Description: Primary antibody against CD1a / HTA1 (Mature Langerhans Cells Marker) (C1A/1506R),PerCP conjugate, Concentration: 0.1mg/mL

CD1a / HTA1 (Mature Langerhans Cells Marker) (rC1A/711) Antibody

BNCP1888-250 250uL
EUR 394
Description: Primary antibody against CD1a / HTA1 (Mature Langerhans Cells Marker) (rC1A/711), PerCP conjugate, Concentration: 0.1mg/mL

CD1a / HTA1 (Mature Langerhans Cells Marker) (C1A/1506R) Antibody

BNCR1506-250 250uL
EUR 383
Description: Primary antibody against CD1a / HTA1 (Mature Langerhans Cells Marker) (C1A/1506R),RPE conjugate, Concentration: 0.1mg/mL

CD1a / HTA1 (Mature Langerhans Cells Marker) (rC1A/711) Antibody

BNCR1888-250 250uL
EUR 394
Description: Primary antibody against CD1a / HTA1 (Mature Langerhans Cells Marker) (rC1A/711), RPE conjugate, Concentration: 0.1mg/mL

CD1a / HTA1 (Mature Langerhans Cells Marker) (C1A/1506R) Antibody

BNCA1506-250 250uL
EUR 383
Description: Primary antibody against CD1a / HTA1 (Mature Langerhans Cells Marker) (C1A/1506R),APC conjugate, Concentration: 0.1mg/mL

CD1a / HTA1 (Mature Langerhans Cells Marker) (rC1A/711) Antibody

BNCA1888-250 250uL
EUR 394
Description: Primary antibody against CD1a / HTA1 (Mature Langerhans Cells Marker) (rC1A/711), APC conjugate, Concentration: 0.1mg/mL

CD1a / HTA1 (Mature Langerhans Cells Marker) (C1A/1506R) Antibody

BNCAP1506-100 100uL
EUR 199
Description: Primary antibody against CD1a / HTA1 (Mature Langerhans Cells Marker) (C1A/1506R),Alkaline Phosphatase conjugate, Concentration: 0.1mg/mL

CD1a / HTA1 (Mature Langerhans Cells Marker) (C1A/1506R) Antibody

BNCAP1506-500 500uL
EUR 544
Description: Primary antibody against CD1a / HTA1 (Mature Langerhans Cells Marker) (C1A/1506R),Alkaline Phosphatase conjugate, Concentration: 0.1mg/mL

CD1a / HTA1 (Mature Langerhans Cells Marker) (rC1A/711) Antibody

BNCAP1888-100 100uL
EUR 233
Description: Primary antibody against CD1a / HTA1 (Mature Langerhans Cells Marker) (rC1A/711), Alkaline Phosphatase conjugate, Concentration: 0.1mg/mL

CD1a / HTA1 (Mature Langerhans Cells Marker) (rC1A/711) Antibody

BNCAP1888-500 500uL
EUR 545
Description: Primary antibody against CD1a / HTA1 (Mature Langerhans Cells Marker) (rC1A/711), Alkaline Phosphatase conjugate, Concentration: 0.1mg/mL

CD1a / HTA1 (Mature Langerhans Cells Marker) (C1A/1506R) Antibody

BNC811506-100 100uL
EUR 199
Description: Primary antibody against CD1a / HTA1 (Mature Langerhans Cells Marker) (C1A/1506R),CF680R conjugate, Concentration: 0.1mg/mL

CD1a / HTA1 (Mature Langerhans Cells Marker) (C1A/1506R) Antibody

BNC811506-500 500uL
EUR 544
Description: Primary antibody against CD1a / HTA1 (Mature Langerhans Cells Marker) (C1A/1506R),CF680R conjugate, Concentration: 0.1mg/mL

CD1a / HTA1 (Mature Langerhans Cells Marker) (rC1A/711) Antibody

BNC811888-100 100uL
EUR 233
Description: Primary antibody against CD1a / HTA1 (Mature Langerhans Cells Marker) (rC1A/711), CF680R conjugate, Concentration: 0.1mg/mL

CD1a / HTA1 (Mature Langerhans Cells Marker) (rC1A/711) Antibody

BNC811888-500 500uL
EUR 545
Description: Primary antibody against CD1a / HTA1 (Mature Langerhans Cells Marker) (rC1A/711), CF680R conjugate, Concentration: 0.1mg/mL

Anti-CD1a / HTA1 (Mature Langerhans Cells Marker) Monoclonal Antibody

M00375 100ug/vial
EUR 397
Description: Mouse Monoclonal CD1a / HTA1 (Mature Langerhans Cells Marker) Antibody. Validated in IHC and tested in Human.

T-Lymphocytes Antibody (APC)

abx415483-100tests 100 tests
EUR 829
  • Shipped within 1 week.

T-Lymphocytes Antibody (FITC)

abx415484-100tests 100 tests
EUR 648
  • Shipped within 1 week.

T-Lymphocytes Antibody (FITC)

abx415542-100tests 100 tests
EUR 648
  • Shipped within 1 week.

Monoclonal CD1a / HTA1 (Mature Langerhans Cells Marker) Antibody, Clone: O10

AMM01439G 7 ml
EUR 484
Description: A Monoclonal antibody against Human CD1a / HTA1 (Mature Langerhans Cells Marker). The antibodies are raised in Mouse and are from clone O10. This antibody is applicable in IHC, IF, FC

Anti-Guinea pig lymphocytes antibody

STJ16100971 1 mg
EUR 562

CD1a / HTA1 (Mature Langerhans Cells Marker); Clone O10 (Concentrate)

RA0031-C.1 0.1 ml
EUR 125

CD1a / HTA1 (Mature Langerhans Cells Marker); Clone O10 (Concentrate)

RA0031-C.5 0.5 ml
EUR 300

Monoclonal CD1a / HTA1 (Mature Langerhans Cells Marker) Antibody, Clone: C1A/711

AMM01441G 7 ml
EUR 484
Description: A Monoclonal antibody against Human CD1a / HTA1 (Mature Langerhans Cells Marker). The antibodies are raised in Mouse and are from clone C1A/711. This antibody is applicable in IHC, IF, FC

anti-CD20 B-lymphocytes

509-A-01mg 0,1 mg
EUR 267.5
  • Category: Antibody, Signal Transduction Antibodies, mAb
Description: anti-CD20 B-lymphocytes

anti-CD20 B-lymphocytes

509-A-1000ug 1000 ug
EUR 1282.5
  • Category: Antibody, Signal Transduction Antibodies, mAb
Description: anti-CD20 B-lymphocytes

anti-CD22 B-lymphocytes

510-A-01mg 0,1 mg
EUR 267.5
  • Category: Antibody, Signal Transduction Antibodies, mAb
Description: anti-CD22 B-lymphocytes

anti-CD22 B-lymphocytes

510-A-1000ug 1000 ug
EUR 1282.5
  • Category: Antibody, Signal Transduction Antibodies, mAb
Description: anti-CD22 B-lymphocytes

Immortalized Bovine Lymphocytes- SV40

T0130 1x106 cells / 1.0 ml Ask for price

CD1a / HTA1 (Mature Langerhans Cells Marker); Clone C1A/711 (Concentrate)

RA0032-C.1 0.1 ml
EUR 125

CD1a / HTA1 (Mature Langerhans Cells Marker); Clone C1A/711 (Concentrate)

RA0032-C.5 0.5 ml
EUR 300

Monoclonal CD1a / HTA1 (Mature Langerhans Cells Marker) Antibody, Clone: O10 + C1A/711

AMM01442G 7 ml
EUR 484
Description: A Monoclonal antibody against Human CD1a / HTA1 (Mature Langerhans Cells Marker). The antibodies are raised in Mouse and are from clone O10 + C1A/711. This antibody is applicable in IHC, IF, FC

CD1a / HTA1 (Mature Langerhans Cells Marker); Clone O10 & C1A/711 (Concentrate)

RA0033-C.1 0.1 ml
EUR 125

CD1a / HTA1 (Mature Langerhans Cells Marker); Clone O10 & C1A/711 (Concentrate)

RA0033-C.5 0.5 ml
EUR 300

Monoclonal CD1a (Mature Langerhans Cells Marker) Antibody - With BSA and Azide, Clone: SPM120

AMM00439G 0.05mg
EUR 396
Description: A Monoclonal antibody against Human CD1a (Mature Langerhans Cells Marker) - With BSA and Azide. The antibodies are raised in Mouse and are from clone SPM120. This antibody is applicable in IHC-P, IF, FC

Monoclonal CD1a (Mature Langerhans Cells Marker) Antibody - Without BSA and Azide, Clone: SPM120

AMM00440G 0.1mg
EUR 484
Description: A Monoclonal antibody against Human CD1a (Mature Langerhans Cells Marker) - Without BSA and Azide. The antibodies are raised in Mouse and are from clone SPM120. This antibody is applicable in IHC-P, IF, FC

Monoclonal CD1a / HTA1 (Mature Langerhans Cells Marker) Antibody - With BSA and Azide, Clone: O10

AMM00172G 0.05mg
EUR 396
Description: A Monoclonal antibody against Human CD1a / HTA1 (Mature Langerhans Cells Marker) - With BSA and Azide. The antibodies are raised in Mouse and are from clone O10. This antibody is applicable in WB, IHC and IF, FC, IP, E

Monoclonal CD1a / HTA1 (Mature Langerhans Cells Marker) Antibody - Without BSA and Azide, Clone: O10

AMM00438G 0.1mg
EUR 484
Description: A Monoclonal antibody against Human CD1a / HTA1 (Mature Langerhans Cells Marker) - Without BSA and Azide. The antibodies are raised in Mouse and are from clone O10. This antibody is applicable in IHC-P, IF, FC

Monoclonal CD1a / HTA1 (Mature Langerhans Cells Marker) Antibody - With BSA and Azide, Clone: 66IIC7

AMM01443G 0.05mg
EUR 396
Description: A Monoclonal antibody against Human CD1a / HTA1 (Mature Langerhans Cells Marker) - With BSA and Azide. The antibodies are raised in Mouse and are from clone 66IIC7. This antibody is applicable in IHC, IF, FC

Monoclonal CD1a / HTA1 (Mature Langerhans Cells Marker) Antibody - Without BSA and Azide, Clone: 66IIC7

AMM01444G 0.1mg
EUR 484
Description: A Monoclonal antibody against Human CD1a / HTA1 (Mature Langerhans Cells Marker) - Without BSA and Azide. The antibodies are raised in Mouse and are from clone 66IIC7. This antibody is applicable in IHC, IF, FC

Monoclonal CD1a / HTA1 (Mature Langerhans Cells Marker) Antibody - With BSA and Azide, Clone: CBT6

AMM01445G 0.05mg
EUR 396
Description: A Monoclonal antibody against Human CD1a / HTA1 (Mature Langerhans Cells Marker) - With BSA and Azide. The antibodies are raised in Mouse and are from clone CBT6. This antibody is applicable in IF, FC

Monoclonal CD1a / HTA1 (Mature Langerhans Cells Marker) Antibody - Without BSA and Azide, Clone: CBT6

AMM01446G 0.1mg
EUR 484
Description: A Monoclonal antibody against Human CD1a / HTA1 (Mature Langerhans Cells Marker) - Without BSA and Azide. The antibodies are raised in Mouse and are from clone CBT6. This antibody is applicable in IF, FC

Monoclonal CD1a / HTA1 (Mature Langerhans Cells Marker) Antibody - With BSA and Azide, Clone: C1A/711

AMM00073G 0.05mg
EUR 396
Description: A Monoclonal antibody against Human CD1a / HTA1 (Mature Langerhans Cells Marker) - With BSA and Azide. The antibodies are raised in Mouse and are from clone C1A/711. This antibody is applicable in WB, IHC and IF, FC, IP, E

Monoclonal CD1a / HTA1 (Mature Langerhans Cells Marker) Antibody - Without BSA and Azide, Clone: C1A/711

AMM00441G 0.1mg
EUR 484
Description: A Monoclonal antibody against Human CD1a / HTA1 (Mature Langerhans Cells Marker) - Without BSA and Azide. The antibodies are raised in Mouse and are from clone C1A/711. This antibody is applicable in IHC-P, IF, FC

Monoclonal CD1a / HTA1 (Mature Langerhans Cells Marker) Antibody - With BSA and Azide, Clone: O10+C1A/711

AMM00173G 0.05mg
EUR 396
Description: A Monoclonal antibody against Human CD1a / HTA1 (Mature Langerhans Cells Marker) - With BSA and Azide. The antibodies are raised in Mouse and are from clone O10+C1A/711. This antibody is applicable in WB, IHC and IF, FC, IP

Monoclonal CD1a / HTA1 (Mature Langerhans Cells Marker) Antibody - Without BSA and Azide, Clone: O10 + C1A/711

AMM00442G 0.1mg
EUR 484
Description: A Monoclonal antibody against Human CD1a / HTA1 (Mature Langerhans Cells Marker) - Without BSA and Azide. The antibodies are raised in Mouse and are from clone O10 + C1A/711. This antibody is applicable in IHC-P, IF, FC

anti-CD26 T/B lymphocytes and macrophages

512-A-01mg 0,1 mg
EUR 267.5
  • Category: Antibody, Signal Transduction Antibodies, mAb
Description: anti-CD26 Activated T, B lymphocytes and macrophages

anti-CD26 T/B lymphocytes and macrophages

512-A-1000ug 1000 ug
EUR 1282.5
  • Category: Antibody, Signal Transduction Antibodies, mAb
Description: anti-CD26 Activated T, B lymphocytes and macrophages

Dendritic Cells/B Cells Antibody

abx412775-02mg 0.2 mg
EUR 565
  • Shipped within 1 week.

Islets of Langerhans, Peptide Aptamer, Biotinylated

AP-317-B 1 mg Ask for price

Islets of Langerhans, Peptide Aptamer, unlabeled

AP-317-U 5 mg Ask for price

Endothelial Cells Antibody

abx411306-01mg 0.1 mg
EUR 704
  • Shipped within 1 week.

Endothelial Cells Antibody

abx411308-05ml 0.5 ml
EUR 606
  • Shipped within 1 week.

Endothelial Cells Antibody

abx413331-2ml 2 ml
EUR 606
  • Shipped within 1 week.

Reticulum Cells Antibody

abx415452-025mg 0.25 mg
EUR 565
  • Shipped within 1 week.

Reticulum Cells Antibody

abx415453-025mg 0.25 mg
EUR 565
  • Shipped within 1 week.

Mitotic Cells antibody

10R-8086 100 ug
EUR 467
Description: Mouse monoclonal Mitotic Cells antibody

Islets of Langerhans, Peptide Aptamer, FITC labelled

AP-317-F 1 mg Ask for price

anti-CD45 RA B-cells, T-cells, NK-cells

516-A-01mg 0,1 mg
EUR 267.5
  • Category: Antibody, Signal Transduction Antibodies, mAb
Description: anti-CD45 RA B-cells, T-cells, NK-cells

anti-CD45 RA B-cells, T-cells, NK-cells

516-A-1000ug 1000 ug
EUR 1282.5
  • Category: Antibody, Signal Transduction Antibodies, mAb
Description: anti-CD45 RA B-cells, T-cells, NK-cells

Fibroblasts/Epithelial Cells Antibody

abx413035-02mg 0.2 mg
EUR 648
  • Shipped within 1 week.

Fibroblasts/Epithelial Cells Antibody

abx413036-25ug 25 ug
EUR 300
  • Shipped within 1 week.

Dendritic/Interdigitating Cells Antibody

abx415668-2ml 2 ml
EUR 606
  • Shipped within 1 week.

Follicular Dendritic Cells antibody

10R-6696 100 ug
EUR 354
Description: Mouse monoclonal Follicular Dendritic Cells antibody

Follicular Dendritic Cells antibody

10R-M164A 500 ug
EUR 705
Description: Mouse monoclonal Follicular Dendritic Cells antibody

Rat Mast Cells antibody

20R-MR030 5 ml
EUR 619
Description: Rabbit polyclonal Rat Mast Cells antibody

Rat Mast Cells antibody

20R-MR031 2 ml
EUR 543
Description: Rabbit polyclonal Rat Mast Cells antibody

Anti-Myeloid cells antibody

STJ16100157 100 µg
EUR 389

Anti-B-cells antibody

STJ16100750 1 mL
EUR 481

Anti-B-cells antibody

STJ16100942 1 mL
EUR 352

Anti-Dendritic Cells antibody

STJ16100970 200 µg
EUR 755

5637 cells

C0002001 One Frozen vial
EUR 485

MB49 cells

C0002004 One Frozen vial
EUR 777

K562 cells

C0003004 One Frozen vial
EUR 455

U937 cells

C0003005 One Frozen vial
EUR 455

Raji cells

C0003009 One Frozen vial
EUR 455

Daudi cells

C0003010 One Frozen vial
EUR 455

RS4;11 cells

C0003012 One Frozen vial
EUR 455

NAMALWA cells

C0003013 One Frozen vial
EUR 455

BJAB cells

C0003016 One Frozen vial
EUR 543

FO cells

C0003017 One Frozen vial
EUR 485

MC116 cells

C0003021 One Frozen vial
EUR 485

P3X63Ag8.653 cells

C0003028 One Frozen vial
EUR 455

REH cells

C0003031 One Frozen vial
EUR 485

Mino cells

C0003033 One Frozen vial
EUR 485

U87MG cells

C0005002 One Frozen vial
EUR 455

B103 cells

C0005003 One Frozen vial
EUR 777

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