Blokada immunologicznych punktów kontrolnych w immunoterapii

Societatea Romana de Stiinte Fiziologice  > immune, Isotype, PCR, peptide >  Blokada immunologicznych punktów kontrolnych w immunoterapii
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Blokada immunologicznych punktów kontrolnych w immunoterapii

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Komórki dendrytyczne i kontrola odporności.

Limfocitele B și T   sunt mediatorii imunității, dar funcția lor este sub controlul celulelor dendritice  . Dendritlce  celulele  din antigeni de captare și de proces periferie, exprimă  limfocite  molecule co-stimulatoare, migrează spre organele limfoide si citokine secreta pentru a initia raspunsuri imune. Acestea activează nu numai  limfocitele , ci tolerează și celulele T   la antigene care sunt înnăscute în organism (auto-antigene), reducând astfel reacțiile autoimune. Odată ce un  tip de celulă neglijat  , celulele dendritice   pot fi acum obținute cu ușurință în cantități suficiente pentru a permite molecula și  celula analiza biologică. Odată cu cunoașterea vine realizarea că aceste  celule  sunt un instrument puternic pentru manipularea sistemului imunitar.

Poprawa czasu przeżycia przy stosowaniu ipilimumabu u pacjentów z przerzutowym czerniakiem.

 

FUNDAL

O îmbunătățire a supraviețuirii globale în rândul pacienților cu melanom metastatic a fost un obiectiv evaziv. În acest studiu de fază 3, ipilimumab – care blochează antigenul asociat four al limfocitelor T citotoxice pentru a potența un  răspuns antitumoral al celulelor T – administrat cu sau fără un vaccin peptidic cu glicoproteină 100 (gp100) a fost comparat cu gp100 singur la pacienții cu metastază tratată anterior melanom.

METODE

Un whole de 676 de pacienți HLA-A * 0201 pozitivi cu melanom de stadiul III sau IV irezecabil, a căror boală progresase în timp ce primeau terapie pentru boala metastatică, au fost repartizați aleatoriu, într-un raport de 3: 1: 1, pentru a primi ipilimumab plus gp100 (403 pacienți) , ipilimumab singur (137) sau gp100 singur (136). Ipilimumab, la o doză de Three mg per kilogram de greutate corporală, a fost administrat cu sau fără gp100 la fiecare Three săptămâni pentru până la patru tratamente (inducție). Pacienții eligibili ar putea primi terapie de reinducție. Obiectivul principal a fost supraviețuirea generală.

REZULTATE

Supraviețuirea globală mediană a fost de 10,Zero luni la pacienții cărora li s-a administrat ipilimumab plus gp100, comparativ cu 6,four luni la pacienții cărora li s-a administrat gp100 singur (raport de risc pentru deces, 0,68; P <0,001). Supraviețuirea globală mediană numai cu ipilimumab a fost de 10,1 luni (raportul de risc pentru deces în comparație cu gp100 singur, 0,66; P = 0,003). Nu s-a detectat nicio diferență în supraviețuirea globală între grupurile de ipilimumab (raportul de risc cu ipilimumab plus gp100, 1,04; P = 0,76). Evenimentele adversarial legate de imunitate de gradul Three sau four au apărut la 10-15% dintre pacienții tratați cu ipilimumab și la 3% tratați numai cu gp100. Au existat 14 decese legate de medicamentele studiate (2,1%), iar 7 au fost asociate cu evenimente adversarial legate de imunitate.

CONCLUZII

Ipilimumab, cu sau fără vaccin peptidic gp100 , comparativ cu gp100 singur, a îmbunătățit supraviețuirea generală la pacienții cu melanom metastatic tratat anterior. Evenimentele adversarial pot fi extreme, de lungă durată sau ambele, dar cele mai multe sunt reversibile cu un tratament adecvat . (Finanțat de Medarex și Bristol-Myers Squibb; numărul ClinicalTrials.gov, NCT00094653.)

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CD1a / HTA1 (Mature Langerhans Cells Marker) (rC1A/711) Antibody

BNC801888-100 100uL
EUR 279.6
Description: Primary antibody against CD1a / HTA1 (Mature Langerhans Cells Marker) (rC1A/711), CF680 conjugate, Concentration: 0.1mg/mL

CD1a / HTA1 (Mature Langerhans Cells Marker) (rC1A/711) Antibody

BNC801888-500 500uL
EUR 654
Description: Primary antibody against CD1a / HTA1 (Mature Langerhans Cells Marker) (rC1A/711), CF680 conjugate, Concentration: 0.1mg/mL

CD1a / HTA1 (Mature Langerhans Cells Marker) (rC1A/711) Antibody

BNC701888-100 100uL
EUR 279.6
Description: Primary antibody against CD1a / HTA1 (Mature Langerhans Cells Marker) (rC1A/711), CF770 conjugate, Concentration: 0.1mg/mL

CD1a / HTA1 (Mature Langerhans Cells Marker) (rC1A/711) Antibody

BNC701888-500 500uL
EUR 654
Description: Primary antibody against CD1a / HTA1 (Mature Langerhans Cells Marker) (rC1A/711), CF770 conjugate, Concentration: 0.1mg/mL

CD1a / HTA1 (Mature Langerhans Cells Marker) (rC1A/711) Antibody

BNC881888-100 100uL
EUR 279.6
Description: Primary antibody against CD1a / HTA1 (Mature Langerhans Cells Marker) (rC1A/711), CF488A conjugate, Concentration: 0.1mg/mL

CD1a / HTA1 (Mature Langerhans Cells Marker) (rC1A/711) Antibody

BNC881888-500 500uL
EUR 654
Description: Primary antibody against CD1a / HTA1 (Mature Langerhans Cells Marker) (rC1A/711), CF488A conjugate, Concentration: 0.1mg/mL

CD1a / HTA1 (Mature Langerhans Cells Marker) (rC1A/711) Antibody

BNC811888-100 100uL
EUR 279.6
Description: Primary antibody against CD1a / HTA1 (Mature Langerhans Cells Marker) (rC1A/711), CF680R conjugate, Concentration: 0.1mg/mL

CD1a / HTA1 (Mature Langerhans Cells Marker) (rC1A/711) Antibody

BNC811888-500 500uL
EUR 654
Description: Primary antibody against CD1a / HTA1 (Mature Langerhans Cells Marker) (rC1A/711), CF680R conjugate, Concentration: 0.1mg/mL

CD1a / HTA1 (Mature Langerhans Cells Marker) (rC1A/711) Antibody

BNC051888-100 100uL
EUR 279.6
Description: Primary antibody against CD1a / HTA1 (Mature Langerhans Cells Marker) (rC1A/711), CF405M conjugate, Concentration: 0.1mg/mL

CD1a / HTA1 (Mature Langerhans Cells Marker) (rC1A/711) Antibody

BNC051888-500 500uL
EUR 654
Description: Primary antibody against CD1a / HTA1 (Mature Langerhans Cells Marker) (rC1A/711), CF405M conjugate, Concentration: 0.1mg/mL

CD1a / HTA1 (Mature Langerhans Cells Marker) (rC1A/711) Antibody

BNC041888-100 100uL
EUR 279.6
Description: Primary antibody against CD1a / HTA1 (Mature Langerhans Cells Marker) (rC1A/711), CF405S conjugate, Concentration: 0.1mg/mL

CD1a / HTA1 (Mature Langerhans Cells Marker) (rC1A/711) Antibody

BNC041888-500 500uL
EUR 654
Description: Primary antibody against CD1a / HTA1 (Mature Langerhans Cells Marker) (rC1A/711), CF405S conjugate, Concentration: 0.1mg/mL

CD1a / HTA1 (Mature Langerhans Cells Marker) (rC1A/711) Antibody

BNC401888-100 100uL
EUR 279.6
Description: Primary antibody against CD1a / HTA1 (Mature Langerhans Cells Marker) (rC1A/711), CF640R conjugate, Concentration: 0.1mg/mL

CD1a / HTA1 (Mature Langerhans Cells Marker) (rC1A/711) Antibody

BNC401888-500 500uL
EUR 654
Description: Primary antibody against CD1a / HTA1 (Mature Langerhans Cells Marker) (rC1A/711), CF640R conjugate, Concentration: 0.1mg/mL

CD1a / HTA1 (Mature Langerhans Cells Marker) (rC1A/711) Antibody

BNCAP1888-100 100uL
EUR 279.6
Description: Primary antibody against CD1a / HTA1 (Mature Langerhans Cells Marker) (rC1A/711), Alkaline Phosphatase conjugate, Concentration: 0.1mg/mL

CD1a / HTA1 (Mature Langerhans Cells Marker) (rC1A/711) Antibody

BNCAP1888-500 500uL
EUR 654
Description: Primary antibody against CD1a / HTA1 (Mature Langerhans Cells Marker) (rC1A/711), Alkaline Phosphatase conjugate, Concentration: 0.1mg/mL

CD1a / HTA1 (Mature Langerhans Cells Marker) (rC1A/711) Antibody

BNCA1888-250 250uL
EUR 472.8
Description: Primary antibody against CD1a / HTA1 (Mature Langerhans Cells Marker) (rC1A/711), APC conjugate, Concentration: 0.1mg/mL

CD1a / HTA1 (Mature Langerhans Cells Marker) (rC1A/711) Antibody

BNCP1888-250 250uL
EUR 472.8
Description: Primary antibody against CD1a / HTA1 (Mature Langerhans Cells Marker) (rC1A/711), PerCP conjugate, Concentration: 0.1mg/mL

CD1a / HTA1 (Mature Langerhans Cells Marker) (rC1A/711) Antibody

BNCR1888-250 250uL
EUR 472.8
Description: Primary antibody against CD1a / HTA1 (Mature Langerhans Cells Marker) (rC1A/711), RPE conjugate, Concentration: 0.1mg/mL

CD1a / HTA1 (Mature Langerhans Cells Marker) (rC1A/711) Antibody

BNCH1888-100 100uL
EUR 279.6
Description: Primary antibody against CD1a / HTA1 (Mature Langerhans Cells Marker) (rC1A/711), Horseradish Peroxidase conjugate, Concentration: 0.1mg/mL

CD1a / HTA1 (Mature Langerhans Cells Marker) (rC1A/711) Antibody

BNCH1888-500 500uL
EUR 654
Description: Primary antibody against CD1a / HTA1 (Mature Langerhans Cells Marker) (rC1A/711), Horseradish Peroxidase conjugate, Concentration: 0.1mg/mL

CD1a / HTA1 (Mature Langerhans Cells Marker) (rC1A/711) Antibody

BNCB1888-100 100uL
EUR 279.6
Description: Primary antibody against CD1a / HTA1 (Mature Langerhans Cells Marker) (rC1A/711), Biotin conjugate, Concentration: 0.1mg/mL

CD1a / HTA1 (Mature Langerhans Cells Marker) (rC1A/711) Antibody

BNCB1888-500 500uL
EUR 654
Description: Primary antibody against CD1a / HTA1 (Mature Langerhans Cells Marker) (rC1A/711), Biotin conjugate, Concentration: 0.1mg/mL

CD1a / HTA1 (Mature Langerhans Cells Marker) (rC1A/711) Antibody

BNUB1888-100 100uL
EUR 316.8
Description: Primary antibody against CD1a / HTA1 (Mature Langerhans Cells Marker) (rC1A/711), Concentration: 0.2mg/mL

CD1a / HTA1 (Mature Langerhans Cells Marker) (rC1A/711) Antibody

BNUB1888-50 50uL
EUR 486
Description: Primary antibody against CD1a / HTA1 (Mature Langerhans Cells Marker) (rC1A/711), 1mg/mL

CD1a / HTA1 (Mature Langerhans Cells Marker) (rC1A/711) Antibody

BNUB1888-500 500uL
EUR 615.6
Description: Primary antibody against CD1a / HTA1 (Mature Langerhans Cells Marker) (rC1A/711), Concentration: 0.2mg/mL

CD1a / HTA1 (Mature Langerhans Cells Marker) (rC1A/711) Antibody

BNC471888-100 100uL
EUR 279.6
Description: Primary antibody against CD1a / HTA1 (Mature Langerhans Cells Marker) (rC1A/711), CF647 conjugate, Concentration: 0.1mg/mL

CD1a / HTA1 (Mature Langerhans Cells Marker) (rC1A/711) Antibody

BNC471888-500 500uL
EUR 654
Description: Primary antibody against CD1a / HTA1 (Mature Langerhans Cells Marker) (rC1A/711), CF647 conjugate, Concentration: 0.1mg/mL

CD1a / HTA1 (Mature Langerhans Cells Marker) (rC1A/711) Antibody

BNC611888-100 100uL
EUR 279.6
Description: Primary antibody against CD1a / HTA1 (Mature Langerhans Cells Marker) (rC1A/711), CF660R conjugate, Concentration: 0.1mg/mL

CD1a / HTA1 (Mature Langerhans Cells Marker) (rC1A/711) Antibody

BNC611888-500 500uL
EUR 654
Description: Primary antibody against CD1a / HTA1 (Mature Langerhans Cells Marker) (rC1A/711), CF660R conjugate, Concentration: 0.1mg/mL

CD1a / HTA1 (Mature Langerhans Cells Marker) (rC1A/711) Antibody

BNC431888-100 100uL
EUR 279.6
Description: Primary antibody against CD1a / HTA1 (Mature Langerhans Cells Marker) (rC1A/711), CF543 conjugate, Concentration: 0.1mg/mL

CD1a / HTA1 (Mature Langerhans Cells Marker) (rC1A/711) Antibody

BNC431888-500 500uL
EUR 654
Description: Primary antibody against CD1a / HTA1 (Mature Langerhans Cells Marker) (rC1A/711), CF543 conjugate, Concentration: 0.1mg/mL

CD1a / HTA1 (Mature Langerhans Cells Marker) (rC1A/711) Antibody

BNC551888-100 100uL
EUR 279.6
Description: Primary antibody against CD1a / HTA1 (Mature Langerhans Cells Marker) (rC1A/711), CF555 conjugate, Concentration: 0.1mg/mL

CD1a / HTA1 (Mature Langerhans Cells Marker) (rC1A/711) Antibody

BNC551888-500 500uL
EUR 654
Description: Primary antibody against CD1a / HTA1 (Mature Langerhans Cells Marker) (rC1A/711), CF555 conjugate, Concentration: 0.1mg/mL

CD1a / HTA1 (Mature Langerhans Cells Marker) (rC1A/711) Antibody

BNC681888-100 100uL
EUR 279.6
Description: Primary antibody against CD1a / HTA1 (Mature Langerhans Cells Marker) (rC1A/711), CF568 conjugate, Concentration: 0.1mg/mL

CD1a / HTA1 (Mature Langerhans Cells Marker) (rC1A/711) Antibody

BNC681888-500 500uL
EUR 654
Description: Primary antibody against CD1a / HTA1 (Mature Langerhans Cells Marker) (rC1A/711), CF568 conjugate, Concentration: 0.1mg/mL

CD1a / HTA1 (Mature Langerhans Cells Marker) (C1A/1506R) Antibody

BNC941506-100 100uL
EUR 238.8
Description: Primary antibody against CD1a / HTA1 (Mature Langerhans Cells Marker) (C1A/1506R),CF594 conjugate, Concentration: 0.1mg/mL

CD1a / HTA1 (Mature Langerhans Cells Marker) (C1A/1506R) Antibody

BNC941506-500 500uL
EUR 652.8
Description: Primary antibody against CD1a / HTA1 (Mature Langerhans Cells Marker) (C1A/1506R),CF594 conjugate, Concentration: 0.1mg/mL

CD1a / HTA1 (Mature Langerhans Cells Marker) (C1A/1506R) Antibody

BNC801506-100 100uL
EUR 238.8
Description: Primary antibody against CD1a / HTA1 (Mature Langerhans Cells Marker) (C1A/1506R),CF680 conjugate, Concentration: 0.1mg/mL

CD1a / HTA1 (Mature Langerhans Cells Marker) (C1A/1506R) Antibody

BNC801506-500 500uL
EUR 652.8
Description: Primary antibody against CD1a / HTA1 (Mature Langerhans Cells Marker) (C1A/1506R),CF680 conjugate, Concentration: 0.1mg/mL

CD1a / HTA1 (Mature Langerhans Cells Marker) (C1A/1506R) Antibody

BNC811506-100 100uL
EUR 238.8
Description: Primary antibody against CD1a / HTA1 (Mature Langerhans Cells Marker) (C1A/1506R),CF680R conjugate, Concentration: 0.1mg/mL

CD1a / HTA1 (Mature Langerhans Cells Marker) (C1A/1506R) Antibody

BNC811506-500 500uL
EUR 652.8
Description: Primary antibody against CD1a / HTA1 (Mature Langerhans Cells Marker) (C1A/1506R),CF680R conjugate, Concentration: 0.1mg/mL

CD1a / HTA1 (Mature Langerhans Cells Marker) (C1A/1506R) Antibody

BNC701506-100 100uL
EUR 238.8
Description: Primary antibody against CD1a / HTA1 (Mature Langerhans Cells Marker) (C1A/1506R),CF770 conjugate, Concentration: 0.1mg/mL

CD1a / HTA1 (Mature Langerhans Cells Marker) (C1A/1506R) Antibody

BNC701506-500 500uL
EUR 652.8
Description: Primary antibody against CD1a / HTA1 (Mature Langerhans Cells Marker) (C1A/1506R),CF770 conjugate, Concentration: 0.1mg/mL

CD1a / HTA1 (Mature Langerhans Cells Marker) (C1A/1506R) Antibody

BNC881506-100 100uL
EUR 238.8
Description: Primary antibody against CD1a / HTA1 (Mature Langerhans Cells Marker) (C1A/1506R),CF488A conjugate, Concentration: 0.1mg/mL

CD1a / HTA1 (Mature Langerhans Cells Marker) (C1A/1506R) Antibody

BNC881506-500 500uL
EUR 652.8
Description: Primary antibody against CD1a / HTA1 (Mature Langerhans Cells Marker) (C1A/1506R),CF488A conjugate, Concentration: 0.1mg/mL

CD1a / HTA1 (Mature Langerhans Cells Marker) (C1A/1506R) Antibody

BNC051506-100 100uL
EUR 238.8
Description: Primary antibody against CD1a / HTA1 (Mature Langerhans Cells Marker) (C1A/1506R),CF405M conjugate, Concentration: 0.1mg/mL

CD1a / HTA1 (Mature Langerhans Cells Marker) (C1A/1506R) Antibody

BNC051506-500 500uL
EUR 652.8
Description: Primary antibody against CD1a / HTA1 (Mature Langerhans Cells Marker) (C1A/1506R),CF405M conjugate, Concentration: 0.1mg/mL

CD1a / HTA1 (Mature Langerhans Cells Marker) (C1A/1506R) Antibody

BNC041506-100 100uL
EUR 238.8
Description: Primary antibody against CD1a / HTA1 (Mature Langerhans Cells Marker) (C1A/1506R),CF405S conjugate, Concentration: 0.1mg/mL

CD1a / HTA1 (Mature Langerhans Cells Marker) (C1A/1506R) Antibody

BNC041506-500 500uL
EUR 652.8
Description: Primary antibody against CD1a / HTA1 (Mature Langerhans Cells Marker) (C1A/1506R),CF405S conjugate, Concentration: 0.1mg/mL

CD1a / HTA1 (Mature Langerhans Cells Marker) (C1A/1506R) Antibody

BNC401506-100 100uL
EUR 238.8
Description: Primary antibody against CD1a / HTA1 (Mature Langerhans Cells Marker) (C1A/1506R),CF640R conjugate, Concentration: 0.1mg/mL

CD1a / HTA1 (Mature Langerhans Cells Marker) (C1A/1506R) Antibody

BNC401506-500 500uL
EUR 652.8
Description: Primary antibody against CD1a / HTA1 (Mature Langerhans Cells Marker) (C1A/1506R),CF640R conjugate, Concentration: 0.1mg/mL

CD1a / HTA1 (Mature Langerhans Cells Marker) (C1A/1506R) Antibody

BNCAP1506-100 100uL
EUR 238.8
Description: Primary antibody against CD1a / HTA1 (Mature Langerhans Cells Marker) (C1A/1506R),Alkaline Phosphatase conjugate, Concentration: 0.1mg/mL

CD1a / HTA1 (Mature Langerhans Cells Marker) (C1A/1506R) Antibody

BNCAP1506-500 500uL
EUR 652.8
Description: Primary antibody against CD1a / HTA1 (Mature Langerhans Cells Marker) (C1A/1506R),Alkaline Phosphatase conjugate, Concentration: 0.1mg/mL

CD1a / HTA1 (Mature Langerhans Cells Marker) (C1A/1506R) Antibody

BNCA1506-250 250uL
EUR 459.6
Description: Primary antibody against CD1a / HTA1 (Mature Langerhans Cells Marker) (C1A/1506R),APC conjugate, Concentration: 0.1mg/mL

CD1a / HTA1 (Mature Langerhans Cells Marker) (C1A/1506R) Antibody

BNCR1506-250 250uL
EUR 459.6
Description: Primary antibody against CD1a / HTA1 (Mature Langerhans Cells Marker) (C1A/1506R),RPE conjugate, Concentration: 0.1mg/mL

CD1a / HTA1 (Mature Langerhans Cells Marker) (C1A/1506R) Antibody

BNCH1506-100 100uL
EUR 238.8
Description: Primary antibody against CD1a / HTA1 (Mature Langerhans Cells Marker) (C1A/1506R),Horseradish Peroxidase conjugate, Concentration: 0.1mg/mL

CD1a / HTA1 (Mature Langerhans Cells Marker) (C1A/1506R) Antibody

BNCH1506-500 500uL
EUR 652.8
Description: Primary antibody against CD1a / HTA1 (Mature Langerhans Cells Marker) (C1A/1506R),Horseradish Peroxidase conjugate, Concentration: 0.1mg/mL

CD1a / HTA1 (Mature Langerhans Cells Marker) (C1A/1506R) Antibody

BNCP1506-250 250uL
EUR 459.6
Description: Primary antibody against CD1a / HTA1 (Mature Langerhans Cells Marker) (C1A/1506R),PerCP conjugate, Concentration: 0.1mg/mL

CD1a / HTA1 (Mature Langerhans Cells Marker) (C1A/1506R) Antibody

BNCB1506-100 100uL
EUR 238.8
Description: Primary antibody against CD1a / HTA1 (Mature Langerhans Cells Marker) (C1A/1506R),Biotin conjugate, Concentration: 0.1mg/mL

CD1a / HTA1 (Mature Langerhans Cells Marker) (C1A/1506R) Antibody

BNCB1506-500 500uL
EUR 652.8
Description: Primary antibody against CD1a / HTA1 (Mature Langerhans Cells Marker) (C1A/1506R),Biotin conjugate, Concentration: 0.1mg/mL

CD1a / HTA1 (Mature Langerhans Cells Marker) (C1A/1506R) Antibody

BNUB1506-100 100uL
EUR 250.8
Description: Primary antibody against CD1a / HTA1 (Mature Langerhans Cells Marker) (C1A/1506R), Concentration: 0.2mg/mL

CD1a / HTA1 (Mature Langerhans Cells Marker) (C1A/1506R) Antibody

BNUB1506-500 500uL
EUR 549.6
Description: Primary antibody against CD1a / HTA1 (Mature Langerhans Cells Marker) (C1A/1506R), Concentration: 0.2mg/mL

CD1a / HTA1 (Mature Langerhans Cells Marker) (C1A/1506R) Antibody

BNUM1506-50 50uL
EUR 474
Description: Primary antibody against CD1a / HTA1 (Mature Langerhans Cells Marker) (C1A/1506R), 1mg/mL

CD1a / HTA1 (Mature Langerhans Cells Marker) (C1A/1506R) Antibody

BNC471506-100 100uL
EUR 238.8
Description: Primary antibody against CD1a / HTA1 (Mature Langerhans Cells Marker) (C1A/1506R),CF647 conjugate, Concentration: 0.1mg/mL

CD1a / HTA1 (Mature Langerhans Cells Marker) (C1A/1506R) Antibody

BNC471506-500 500uL
EUR 652.8
Description: Primary antibody against CD1a / HTA1 (Mature Langerhans Cells Marker) (C1A/1506R),CF647 conjugate, Concentration: 0.1mg/mL

CD1a / HTA1 (Mature Langerhans Cells Marker) (C1A/1506R) Antibody

BNC611506-100 100uL
EUR 238.8
Description: Primary antibody against CD1a / HTA1 (Mature Langerhans Cells Marker) (C1A/1506R),CF660R conjugate, Concentration: 0.1mg/mL

CD1a / HTA1 (Mature Langerhans Cells Marker) (C1A/1506R) Antibody

BNC611506-500 500uL
EUR 652.8
Description: Primary antibody against CD1a / HTA1 (Mature Langerhans Cells Marker) (C1A/1506R),CF660R conjugate, Concentration: 0.1mg/mL

CD1a / HTA1 (Mature Langerhans Cells Marker) (C1A/1506R) Antibody

BNC431506-100 100uL
EUR 238.8
Description: Primary antibody against CD1a / HTA1 (Mature Langerhans Cells Marker) (C1A/1506R),CF543 conjugate, Concentration: 0.1mg/mL

CD1a / HTA1 (Mature Langerhans Cells Marker) (C1A/1506R) Antibody

BNC431506-500 500uL
EUR 652.8
Description: Primary antibody against CD1a / HTA1 (Mature Langerhans Cells Marker) (C1A/1506R),CF543 conjugate, Concentration: 0.1mg/mL

CD1a / HTA1 (Mature Langerhans Cells Marker) (C1A/1506R) Antibody

BNC551506-100 100uL
EUR 238.8
Description: Primary antibody against CD1a / HTA1 (Mature Langerhans Cells Marker) (C1A/1506R),CF555 conjugate, Concentration: 0.1mg/mL

CD1a / HTA1 (Mature Langerhans Cells Marker) (C1A/1506R) Antibody

BNC551506-500 500uL
EUR 652.8
Description: Primary antibody against CD1a / HTA1 (Mature Langerhans Cells Marker) (C1A/1506R),CF555 conjugate, Concentration: 0.1mg/mL

CD1a / HTA1 (Mature Langerhans Cells Marker) (C1A/1506R) Antibody

BNC681506-100 100uL
EUR 238.8
Description: Primary antibody against CD1a / HTA1 (Mature Langerhans Cells Marker) (C1A/1506R),CF568 conjugate, Concentration: 0.1mg/mL

CD1a / HTA1 (Mature Langerhans Cells Marker) (C1A/1506R) Antibody

BNC681506-500 500uL
EUR 652.8
Description: Primary antibody against CD1a / HTA1 (Mature Langerhans Cells Marker) (C1A/1506R),CF568 conjugate, Concentration: 0.1mg/mL

Monoclonal CD1a (Mature Langerhans Cells Marker) Antibody - With BSA and Azide, Clone: SPM120

AMM00439G 0.05mg
EUR 475.2
Description: A Monoclonal antibody against Human CD1a (Mature Langerhans Cells Marker) - With BSA and Azide. The antibodies are raised in Mouse and are from clone SPM120. This antibody is applicable in IHC-P, IF, FC

Monoclonal CD1a / HTA1 (Mature Langerhans Cells Marker) Antibody - With BSA and Azide, Clone: CBT6

AMM01445G 0.05mg
EUR 475.2
Description: A Monoclonal antibody against Human CD1a / HTA1 (Mature Langerhans Cells Marker) - With BSA and Azide. The antibodies are raised in Mouse and are from clone CBT6. This antibody is applicable in IF, FC

Monoclonal CD1a / HTA1 (Mature Langerhans Cells Marker) Antibody - With BSA and Azide, Clone: O10

AMM00172G 0.05mg
EUR 475.2
Description: A Monoclonal antibody against Human CD1a / HTA1 (Mature Langerhans Cells Marker) - With BSA and Azide. The antibodies are raised in Mouse and are from clone O10. This antibody is applicable in WB, IHC and IF, FC, IP, E

Monoclonal CD1a (Mature Langerhans Cells Marker) Antibody - Without BSA and Azide, Clone: SPM120

AMM00440G 0.1mg
EUR 580.8
Description: A Monoclonal antibody against Human CD1a (Mature Langerhans Cells Marker) - Without BSA and Azide. The antibodies are raised in Mouse and are from clone SPM120. This antibody is applicable in IHC-P, IF, FC

Anti-CD1a / HTA1 (Mature Langerhans Cells Marker) Monoclonal Antibody

M00375 100ug/vial
EUR 476.4
Description: Mouse Monoclonal CD1a / HTA1 (Mature Langerhans Cells Marker) Antibody. Validated in IHC and tested in Human.

Monoclonal CD1a / HTA1 (Mature Langerhans Cells Marker) Antibody - With BSA and Azide, Clone: 66IIC7

AMM01443G 0.05mg
EUR 475.2
Description: A Monoclonal antibody against Human CD1a / HTA1 (Mature Langerhans Cells Marker) - With BSA and Azide. The antibodies are raised in Mouse and are from clone 66IIC7. This antibody is applicable in IHC, IF, FC

Monoclonal CD1a / HTA1 (Mature Langerhans Cells Marker) Antibody - Without BSA and Azide, Clone: O10

AMM00438G 0.1mg
EUR 580.8
Description: A Monoclonal antibody against Human CD1a / HTA1 (Mature Langerhans Cells Marker) - Without BSA and Azide. The antibodies are raised in Mouse and are from clone O10. This antibody is applicable in IHC-P, IF, FC

Monoclonal CD1a (Mature Langerhans Cells Marker) Antibody, Clone: SPM120

AMM01440G 7 ml
EUR 580.8
Description: A Monoclonal antibody against Human CD1a (Mature Langerhans Cells Marker). The antibodies are raised in Mouse and are from clone SPM120. This antibody is applicable in IHC, IF, FC

Monoclonal CD1a / HTA1 (Mature Langerhans Cells Marker) Antibody - With BSA and Azide, Clone: C1A/711

AMM00073G 0.05mg
EUR 475.2
Description: A Monoclonal antibody against Human CD1a / HTA1 (Mature Langerhans Cells Marker) - With BSA and Azide. The antibodies are raised in Mouse and are from clone C1A/711. This antibody is applicable in WB, IHC and IF, FC, IP, E

Monoclonal CD1a / HTA1 (Mature Langerhans Cells Marker) Antibody - Without BSA and Azide, Clone: CBT6

AMM01446G 0.1mg
EUR 580.8
Description: A Monoclonal antibody against Human CD1a / HTA1 (Mature Langerhans Cells Marker) - Without BSA and Azide. The antibodies are raised in Mouse and are from clone CBT6. This antibody is applicable in IF, FC

Monoclonal CD1a / HTA1 (Mature Langerhans Cells Marker) Antibody, Clone: O10

AMM01439G 7 ml
EUR 580.8
Description: A Monoclonal antibody against Human CD1a / HTA1 (Mature Langerhans Cells Marker). The antibodies are raised in Mouse and are from clone O10. This antibody is applicable in IHC, IF, FC

Monoclonal CD1a / HTA1 (Mature Langerhans Cells Marker) Antibody - Without BSA and Azide, Clone: C1A/711

AMM00441G 0.1mg
EUR 580.8
Description: A Monoclonal antibody against Human CD1a / HTA1 (Mature Langerhans Cells Marker) - Without BSA and Azide. The antibodies are raised in Mouse and are from clone C1A/711. This antibody is applicable in IHC-P, IF, FC

Monoclonal CD1a / HTA1 (Mature Langerhans Cells Marker) Antibody - Without BSA and Azide, Clone: 66IIC7

AMM01444G 0.1mg
EUR 580.8
Description: A Monoclonal antibody against Human CD1a / HTA1 (Mature Langerhans Cells Marker) - Without BSA and Azide. The antibodies are raised in Mouse and are from clone 66IIC7. This antibody is applicable in IHC, IF, FC

Monoclonal CD1a / HTA1 (Mature Langerhans Cells Marker) Antibody - With BSA and Azide, Clone: O10+C1A/711

AMM00173G 0.05mg
EUR 475.2
Description: A Monoclonal antibody against Human CD1a / HTA1 (Mature Langerhans Cells Marker) - With BSA and Azide. The antibodies are raised in Mouse and are from clone O10+C1A/711. This antibody is applicable in WB, IHC and IF, FC, IP

Anti-Guinea pig lymphocytes antibody

STJ16100971 1 mg
EUR 674.4

Monoclonal CD1a / HTA1 (Mature Langerhans Cells Marker) Antibody, Clone: C1A/711

AMM01441G 7 ml
EUR 580.8
Description: A Monoclonal antibody against Human CD1a / HTA1 (Mature Langerhans Cells Marker). The antibodies are raised in Mouse and are from clone C1A/711. This antibody is applicable in IHC, IF, FC

Monoclonal CD1a / HTA1 (Mature Langerhans Cells Marker) Antibody - Without BSA and Azide, Clone: O10 + C1A/711

AMM00442G 0.1mg
EUR 580.8
Description: A Monoclonal antibody against Human CD1a / HTA1 (Mature Langerhans Cells Marker) - Without BSA and Azide. The antibodies are raised in Mouse and are from clone O10 + C1A/711. This antibody is applicable in IHC-P, IF, FC

Monoclonal CD1a / HTA1 (Mature Langerhans Cells Marker) Antibody, Clone: O10 + C1A/711

AMM01442G 7 ml
EUR 580.8
Description: A Monoclonal antibody against Human CD1a / HTA1 (Mature Langerhans Cells Marker). The antibodies are raised in Mouse and are from clone O10 + C1A/711. This antibody is applicable in IHC, IF, FC

CD1a / HTA1 (Mature Langerhans Cells Marker); Clone O10 (Concentrate)

RA0031-C.1 0.1 ml
EUR 150

CD1a / HTA1 (Mature Langerhans Cells Marker); Clone O10 (Concentrate)

RA0031-C.5 0.5 ml
EUR 360

CD1a / HTA1 (Mature Langerhans Cells Marker); Clone C1A/711 (Concentrate)

RA0032-C.1 0.1 ml
EUR 150

CD1a / HTA1 (Mature Langerhans Cells Marker); Clone C1A/711 (Concentrate)

RA0032-C.5 0.5 ml
EUR 360

CD1a / HTA1 (Mature Langerhans Cells Marker); Clone O10 & C1A/711 (Concentrate)

RA0033-C.1 0.1 ml
EUR 150

CD1a / HTA1 (Mature Langerhans Cells Marker); Clone O10 & C1A/711 (Concentrate)

RA0033-C.5 0.5 ml
EUR 360

anti-CD26 T/B lymphocytes and macrophages

512-A-01mg 0,1 mg
EUR 321
Description: anti-CD26 Activated T, B lymphocytes and macrophages

anti-CD26 T/B lymphocytes and macrophages

512-A-1000ug 1000 ug
EUR 1539
Description: anti-CD26 Activated T, B lymphocytes and macrophages

Blokada immunologicznych punktów kontrolnych w immunoterapii raka.

Printre cele mai promițătoare abordări ale activării imunității terapeutice antitumorale se numără blocada punctelor de management imune. Punctele de management imune se referă la o mulțime de căi inhibitorii conectate la sistemul imunitar care sunt cruciale pentru menținerea autotoleranței și modularea duratei și amplitudinii răspunsurilor imune fiziologice în țesuturile periferice, în scopul de a minimiza deteriorarea colaterală a țesuturilor. Acum este clar că tumorile cooptează anumite căi ale punctelor de management imunitar ca un mecanism main de rezistență imună, în particular împotriva celulelor T   care sunt specifice antigenelor tumorale.

Deoarece multe dintre punctele de management imune sunt inițiate de interacțiunile ligand-receptor , ele pot fi ușor blocate de anticorpi sau modulate de forme recombinate de liganzi sau receptori. Anticorpii citotoxici ai antigenului four asociat cu limfocitele T (CTLA4) au fost primii din această clasă de imunoterapii care au obținut aprobarea Administrației SUA pentru Alimente și Medicamente (FDA). Descoperirile clinice preliminare cu blocante ale proteinelor suplimentare ale punctului de management imun, cum ar fi  proteina programată  1 a morții celulare (PD1), indică oportunități largi și numerous de a spori imunitatea antitumorală cu potențialul de a produce răspunsuri clinice durabile.

Kontrola rozwoju limfocytów T regulatorowych przez czynnik transkrypcyjny Foxp3.

 

Celulele T de reglementare   se angajează în menținerea autotoleranței imunologice prin suprimarea activă a limfocitelor auto-reactive  . Cu toate acestea, se știe puțin despre mecanismul molecular al dezvoltării lor. Aici arătăm că Foxp3, care codifică un issue de transcripție care este genetic defect într-un sindrom autoimun și inflamator la oameni și șoareci, este exprimat în mod particular în celulele T reglatoare CD4 + care apar în mod pure  . In plus, transferul de gene retrovirale de Foxp3 convertește T naive  celule  spre un T de reglementare  de celule  fenotip comparable cu cel al produsului pure T reglatoare CD4 +  celule . Astfel, Foxp3 este o genă reglatoare cheie pentru dezvoltarea reglatorului T celule .

Przewlekłe zapalenie tłuszczu odgrywa kluczową rolę w rozwoju insulinooporności związanej z otyłością.

 

Rezistența la insulină apare din incapacitatea insulinei de a acționa regular în reglarea metabolismului nutrienților în țesuturile periferice. Dovezi în creștere din studiile populației umane și cercetările pe animale au stabilit corelații, precum și legături cauzale între inflamația cronică și rezistența la insulină. Cu toate acestea, căile moleculare de bază sunt în mare parte necunoscute. În acest raport, arătăm că multe inflamații și gene specifice macrofagelor sunt reglate în mod dramatic în sus în țesutul adipos alb (WAT) în modele de șoarece de obezitate genetică și bogată în grăsimi indusă de dietă (DIO).

Reglarea ascendentă este crescută progresiv în WAT la șoareci cu DIO și precede o creștere dramatică a nivelului de insulină circulantă. După tratamentul cu rosiglitazonă, un medicament sensibilizant la insulină, aceste gene originate de macrofage sunt reglate în jos. Histologic, există dovezi de infiltrare semnificativă a macrofagelor, dar nu neutrofile și  limfocite , în WAT șoarecilor obezi, cu semne de lipoliza adipocitelor și formarea de gigant multinucleate  celule. Aceste date sugerează că macrofagele din WAT joacă un rol activ în obezitatea morbidă și că activitățile inflamatorii legate de macrofage pot contribui la patogeneza rezistenței la insulină indusă de obezitate. Propunem că rezistența la insulină legată de obezitate este, cel puțin parțial, o boală inflamatorie cronică inițiată în țesutul adipos.

Dwa podzbiory limfocytów T pamięci o różnych potencjałach naprowadzania i funkcjach efektorowych.

Limfocitele T naive   călătoresc în  zonele celulelor T ale organelor limfoide secundare în căutarea antigenului prezentat de celulele dendritice  . Odată activate, acestea proliferează viguros, generând celule efectoare   care pot migra către  zonele celulelor B sau către țesuturile inflamate. O fracțiune din limfocitele T amorsate   persistă ca celule de memorie circulante   care pot conferi protecție și pot da, la provocarea secundară, un răspuns calitativ diferit și îmbunătățit cantitativ. Natura  celulelor  care mediază diferitele fațete ale memoriei imunologice rămâne nerezolvată.

Aici arătăm că expresia CCR7, un receptor de chemokine care controlează aderarea la organele limfoide secundare, împarte celulele T de memorie umană   în două subseturi funcționale distincte. CCR7 – celulele de memorie   exprimă receptori pentru migrația către țesuturile inflamate și prezintă funcția efectoare imediate. În schimb, celulele de memorie CCR7 +   exprimă receptori de  aderare  la ganglionii limfatici și nu au funcție efectoare imediate, dar stimulează eficient celulele dendritice  și se diferențiază în celule efectoare CCR7  după stimulare secundară. Celulele CCR7 + și CCR7-T  , pe care le-am numit memorie centrală (TCM) și memorie efectoare (TEM), se diferențiază în mod pas cu pas de celulele T naive , persistă ani de zile după imunizare și allow o diviziune a muncii în răspunsul de memorie.

 

CD1a / HTA1 (Mature Langerhans Cells Marker) (rC1A/711) Antibody

BNC701888-100 100uL
EUR 279.6
Description: Primary antibody against CD1a / HTA1 (Mature Langerhans Cells Marker) (rC1A/711), CF770 conjugate, Concentration: 0.1mg/mL

CD1a / HTA1 (Mature Langerhans Cells Marker) (rC1A/711) Antibody

BNC701888-500 500uL
EUR 654
Description: Primary antibody against CD1a / HTA1 (Mature Langerhans Cells Marker) (rC1A/711), CF770 conjugate, Concentration: 0.1mg/mL

CD1a / HTA1 (Mature Langerhans Cells Marker) (rC1A/711) Antibody

BNC881888-100 100uL
EUR 279.6
Description: Primary antibody against CD1a / HTA1 (Mature Langerhans Cells Marker) (rC1A/711), CF488A conjugate, Concentration: 0.1mg/mL

CD1a / HTA1 (Mature Langerhans Cells Marker) (rC1A/711) Antibody

BNC881888-500 500uL
EUR 654
Description: Primary antibody against CD1a / HTA1 (Mature Langerhans Cells Marker) (rC1A/711), CF488A conjugate, Concentration: 0.1mg/mL

CD1a / HTA1 (Mature Langerhans Cells Marker) (rC1A/711) Antibody

BNC811888-100 100uL
EUR 279.6
Description: Primary antibody against CD1a / HTA1 (Mature Langerhans Cells Marker) (rC1A/711), CF680R conjugate, Concentration: 0.1mg/mL

CD1a / HTA1 (Mature Langerhans Cells Marker) (rC1A/711) Antibody

BNC811888-500 500uL
EUR 654
Description: Primary antibody against CD1a / HTA1 (Mature Langerhans Cells Marker) (rC1A/711), CF680R conjugate, Concentration: 0.1mg/mL

CD1a / HTA1 (Mature Langerhans Cells Marker) (rC1A/711) Antibody

BNC051888-100 100uL
EUR 279.6
Description: Primary antibody against CD1a / HTA1 (Mature Langerhans Cells Marker) (rC1A/711), CF405M conjugate, Concentration: 0.1mg/mL

CD1a / HTA1 (Mature Langerhans Cells Marker) (rC1A/711) Antibody

BNC051888-500 500uL
EUR 654
Description: Primary antibody against CD1a / HTA1 (Mature Langerhans Cells Marker) (rC1A/711), CF405M conjugate, Concentration: 0.1mg/mL

CD1a / HTA1 (Mature Langerhans Cells Marker) (rC1A/711) Antibody

BNC041888-100 100uL
EUR 279.6
Description: Primary antibody against CD1a / HTA1 (Mature Langerhans Cells Marker) (rC1A/711), CF405S conjugate, Concentration: 0.1mg/mL

CD1a / HTA1 (Mature Langerhans Cells Marker) (rC1A/711) Antibody

BNC041888-500 500uL
EUR 654
Description: Primary antibody against CD1a / HTA1 (Mature Langerhans Cells Marker) (rC1A/711), CF405S conjugate, Concentration: 0.1mg/mL

CD1a / HTA1 (Mature Langerhans Cells Marker) (rC1A/711) Antibody

BNC401888-100 100uL
EUR 279.6
Description: Primary antibody against CD1a / HTA1 (Mature Langerhans Cells Marker) (rC1A/711), CF640R conjugate, Concentration: 0.1mg/mL

CD1a / HTA1 (Mature Langerhans Cells Marker) (rC1A/711) Antibody

BNC401888-500 500uL
EUR 654
Description: Primary antibody against CD1a / HTA1 (Mature Langerhans Cells Marker) (rC1A/711), CF640R conjugate, Concentration: 0.1mg/mL

CD1a / HTA1 (Mature Langerhans Cells Marker) (rC1A/711) Antibody

BNCAP1888-100 100uL
EUR 279.6
Description: Primary antibody against CD1a / HTA1 (Mature Langerhans Cells Marker) (rC1A/711), Alkaline Phosphatase conjugate, Concentration: 0.1mg/mL

CD1a / HTA1 (Mature Langerhans Cells Marker) (rC1A/711) Antibody

BNCAP1888-500 500uL
EUR 654
Description: Primary antibody against CD1a / HTA1 (Mature Langerhans Cells Marker) (rC1A/711), Alkaline Phosphatase conjugate, Concentration: 0.1mg/mL

CD1a / HTA1 (Mature Langerhans Cells Marker) (rC1A/711) Antibody

BNCA1888-250 250uL
EUR 472.8
Description: Primary antibody against CD1a / HTA1 (Mature Langerhans Cells Marker) (rC1A/711), APC conjugate, Concentration: 0.1mg/mL

CD1a / HTA1 (Mature Langerhans Cells Marker) (rC1A/711) Antibody

BNCP1888-250 250uL
EUR 472.8
Description: Primary antibody against CD1a / HTA1 (Mature Langerhans Cells Marker) (rC1A/711), PerCP conjugate, Concentration: 0.1mg/mL

CD1a / HTA1 (Mature Langerhans Cells Marker) (rC1A/711) Antibody

BNCR1888-250 250uL
EUR 472.8
Description: Primary antibody against CD1a / HTA1 (Mature Langerhans Cells Marker) (rC1A/711), RPE conjugate, Concentration: 0.1mg/mL

CD1a / HTA1 (Mature Langerhans Cells Marker) (rC1A/711) Antibody

BNCH1888-100 100uL
EUR 279.6
Description: Primary antibody against CD1a / HTA1 (Mature Langerhans Cells Marker) (rC1A/711), Horseradish Peroxidase conjugate, Concentration: 0.1mg/mL

CD1a / HTA1 (Mature Langerhans Cells Marker) (rC1A/711) Antibody

BNCH1888-500 500uL
EUR 654
Description: Primary antibody against CD1a / HTA1 (Mature Langerhans Cells Marker) (rC1A/711), Horseradish Peroxidase conjugate, Concentration: 0.1mg/mL

CD1a / HTA1 (Mature Langerhans Cells Marker) (rC1A/711) Antibody

BNCB1888-100 100uL
EUR 279.6
Description: Primary antibody against CD1a / HTA1 (Mature Langerhans Cells Marker) (rC1A/711), Biotin conjugate, Concentration: 0.1mg/mL

CD1a / HTA1 (Mature Langerhans Cells Marker) (rC1A/711) Antibody

BNCB1888-500 500uL
EUR 654
Description: Primary antibody against CD1a / HTA1 (Mature Langerhans Cells Marker) (rC1A/711), Biotin conjugate, Concentration: 0.1mg/mL

CD1a / HTA1 (Mature Langerhans Cells Marker) (rC1A/711) Antibody

BNUB1888-100 100uL
EUR 316.8
Description: Primary antibody against CD1a / HTA1 (Mature Langerhans Cells Marker) (rC1A/711), Concentration: 0.2mg/mL

CD1a / HTA1 (Mature Langerhans Cells Marker) (rC1A/711) Antibody

BNUB1888-50 50uL
EUR 486
Description: Primary antibody against CD1a / HTA1 (Mature Langerhans Cells Marker) (rC1A/711), 1mg/mL

CD1a / HTA1 (Mature Langerhans Cells Marker) (rC1A/711) Antibody

BNUB1888-500 500uL
EUR 615.6
Description: Primary antibody against CD1a / HTA1 (Mature Langerhans Cells Marker) (rC1A/711), Concentration: 0.2mg/mL

CD1a / HTA1 (Mature Langerhans Cells Marker) (rC1A/711) Antibody

BNC471888-100 100uL
EUR 279.6
Description: Primary antibody against CD1a / HTA1 (Mature Langerhans Cells Marker) (rC1A/711), CF647 conjugate, Concentration: 0.1mg/mL

CD1a / HTA1 (Mature Langerhans Cells Marker) (rC1A/711) Antibody

BNC471888-500 500uL
EUR 654
Description: Primary antibody against CD1a / HTA1 (Mature Langerhans Cells Marker) (rC1A/711), CF647 conjugate, Concentration: 0.1mg/mL

CD1a / HTA1 (Mature Langerhans Cells Marker) (rC1A/711) Antibody

BNC611888-100 100uL
EUR 279.6
Description: Primary antibody against CD1a / HTA1 (Mature Langerhans Cells Marker) (rC1A/711), CF660R conjugate, Concentration: 0.1mg/mL

CD1a / HTA1 (Mature Langerhans Cells Marker) (rC1A/711) Antibody

BNC611888-500 500uL
EUR 654
Description: Primary antibody against CD1a / HTA1 (Mature Langerhans Cells Marker) (rC1A/711), CF660R conjugate, Concentration: 0.1mg/mL

CD1a / HTA1 (Mature Langerhans Cells Marker) (rC1A/711) Antibody

BNC431888-100 100uL
EUR 279.6
Description: Primary antibody against CD1a / HTA1 (Mature Langerhans Cells Marker) (rC1A/711), CF543 conjugate, Concentration: 0.1mg/mL

CD1a / HTA1 (Mature Langerhans Cells Marker) (rC1A/711) Antibody

BNC431888-500 500uL
EUR 654
Description: Primary antibody against CD1a / HTA1 (Mature Langerhans Cells Marker) (rC1A/711), CF543 conjugate, Concentration: 0.1mg/mL

CD1a / HTA1 (Mature Langerhans Cells Marker) (rC1A/711) Antibody

BNC551888-100 100uL
EUR 279.6
Description: Primary antibody against CD1a / HTA1 (Mature Langerhans Cells Marker) (rC1A/711), CF555 conjugate, Concentration: 0.1mg/mL

CD1a / HTA1 (Mature Langerhans Cells Marker) (rC1A/711) Antibody

BNC551888-500 500uL
EUR 654
Description: Primary antibody against CD1a / HTA1 (Mature Langerhans Cells Marker) (rC1A/711), CF555 conjugate, Concentration: 0.1mg/mL

CD1a / HTA1 (Mature Langerhans Cells Marker) (rC1A/711) Antibody

BNC681888-100 100uL
EUR 279.6
Description: Primary antibody against CD1a / HTA1 (Mature Langerhans Cells Marker) (rC1A/711), CF568 conjugate, Concentration: 0.1mg/mL

CD1a / HTA1 (Mature Langerhans Cells Marker) (rC1A/711) Antibody

BNC681888-500 500uL
EUR 654
Description: Primary antibody against CD1a / HTA1 (Mature Langerhans Cells Marker) (rC1A/711), CF568 conjugate, Concentration: 0.1mg/mL

CD1a / HTA1 (Mature Langerhans Cells Marker) (C1A/1506R) Antibody

BNC941506-100 100uL
EUR 238.8
Description: Primary antibody against CD1a / HTA1 (Mature Langerhans Cells Marker) (C1A/1506R),CF594 conjugate, Concentration: 0.1mg/mL

CD1a / HTA1 (Mature Langerhans Cells Marker) (C1A/1506R) Antibody

BNC941506-500 500uL
EUR 652.8
Description: Primary antibody against CD1a / HTA1 (Mature Langerhans Cells Marker) (C1A/1506R),CF594 conjugate, Concentration: 0.1mg/mL

CD1a / HTA1 (Mature Langerhans Cells Marker) (C1A/1506R) Antibody

BNC801506-100 100uL
EUR 238.8
Description: Primary antibody against CD1a / HTA1 (Mature Langerhans Cells Marker) (C1A/1506R),CF680 conjugate, Concentration: 0.1mg/mL

CD1a / HTA1 (Mature Langerhans Cells Marker) (C1A/1506R) Antibody

BNC801506-500 500uL
EUR 652.8
Description: Primary antibody against CD1a / HTA1 (Mature Langerhans Cells Marker) (C1A/1506R),CF680 conjugate, Concentration: 0.1mg/mL

CD1a / HTA1 (Mature Langerhans Cells Marker) (C1A/1506R) Antibody

BNC811506-100 100uL
EUR 238.8
Description: Primary antibody against CD1a / HTA1 (Mature Langerhans Cells Marker) (C1A/1506R),CF680R conjugate, Concentration: 0.1mg/mL

CD1a / HTA1 (Mature Langerhans Cells Marker) (C1A/1506R) Antibody

BNC811506-500 500uL
EUR 652.8
Description: Primary antibody against CD1a / HTA1 (Mature Langerhans Cells Marker) (C1A/1506R),CF680R conjugate, Concentration: 0.1mg/mL

CD1a / HTA1 (Mature Langerhans Cells Marker) (C1A/1506R) Antibody

BNC701506-100 100uL
EUR 238.8
Description: Primary antibody against CD1a / HTA1 (Mature Langerhans Cells Marker) (C1A/1506R),CF770 conjugate, Concentration: 0.1mg/mL

CD1a / HTA1 (Mature Langerhans Cells Marker) (C1A/1506R) Antibody

BNC701506-500 500uL
EUR 652.8
Description: Primary antibody against CD1a / HTA1 (Mature Langerhans Cells Marker) (C1A/1506R),CF770 conjugate, Concentration: 0.1mg/mL

CD1a / HTA1 (Mature Langerhans Cells Marker) (C1A/1506R) Antibody

BNC881506-100 100uL
EUR 238.8
Description: Primary antibody against CD1a / HTA1 (Mature Langerhans Cells Marker) (C1A/1506R),CF488A conjugate, Concentration: 0.1mg/mL

CD1a / HTA1 (Mature Langerhans Cells Marker) (C1A/1506R) Antibody

BNC881506-500 500uL
EUR 652.8
Description: Primary antibody against CD1a / HTA1 (Mature Langerhans Cells Marker) (C1A/1506R),CF488A conjugate, Concentration: 0.1mg/mL

CD1a / HTA1 (Mature Langerhans Cells Marker) (C1A/1506R) Antibody

BNC051506-100 100uL
EUR 238.8
Description: Primary antibody against CD1a / HTA1 (Mature Langerhans Cells Marker) (C1A/1506R),CF405M conjugate, Concentration: 0.1mg/mL

CD1a / HTA1 (Mature Langerhans Cells Marker) (C1A/1506R) Antibody

BNC051506-500 500uL
EUR 652.8
Description: Primary antibody against CD1a / HTA1 (Mature Langerhans Cells Marker) (C1A/1506R),CF405M conjugate, Concentration: 0.1mg/mL

CD1a / HTA1 (Mature Langerhans Cells Marker) (C1A/1506R) Antibody

BNC041506-100 100uL
EUR 238.8
Description: Primary antibody against CD1a / HTA1 (Mature Langerhans Cells Marker) (C1A/1506R),CF405S conjugate, Concentration: 0.1mg/mL

CD1a / HTA1 (Mature Langerhans Cells Marker) (C1A/1506R) Antibody

BNC041506-500 500uL
EUR 652.8
Description: Primary antibody against CD1a / HTA1 (Mature Langerhans Cells Marker) (C1A/1506R),CF405S conjugate, Concentration: 0.1mg/mL

CD1a / HTA1 (Mature Langerhans Cells Marker) (C1A/1506R) Antibody

BNC401506-100 100uL
EUR 238.8
Description: Primary antibody against CD1a / HTA1 (Mature Langerhans Cells Marker) (C1A/1506R),CF640R conjugate, Concentration: 0.1mg/mL

CD1a / HTA1 (Mature Langerhans Cells Marker) (C1A/1506R) Antibody

BNC401506-500 500uL
EUR 652.8
Description: Primary antibody against CD1a / HTA1 (Mature Langerhans Cells Marker) (C1A/1506R),CF640R conjugate, Concentration: 0.1mg/mL

CD1a / HTA1 (Mature Langerhans Cells Marker) (C1A/1506R) Antibody

BNCAP1506-100 100uL
EUR 238.8
Description: Primary antibody against CD1a / HTA1 (Mature Langerhans Cells Marker) (C1A/1506R),Alkaline Phosphatase conjugate, Concentration: 0.1mg/mL

CD1a / HTA1 (Mature Langerhans Cells Marker) (C1A/1506R) Antibody

BNCAP1506-500 500uL
EUR 652.8
Description: Primary antibody against CD1a / HTA1 (Mature Langerhans Cells Marker) (C1A/1506R),Alkaline Phosphatase conjugate, Concentration: 0.1mg/mL

CD1a / HTA1 (Mature Langerhans Cells Marker) (C1A/1506R) Antibody

BNCA1506-250 250uL
EUR 459.6
Description: Primary antibody against CD1a / HTA1 (Mature Langerhans Cells Marker) (C1A/1506R),APC conjugate, Concentration: 0.1mg/mL

CD1a / HTA1 (Mature Langerhans Cells Marker) (C1A/1506R) Antibody

BNCR1506-250 250uL
EUR 459.6
Description: Primary antibody against CD1a / HTA1 (Mature Langerhans Cells Marker) (C1A/1506R),RPE conjugate, Concentration: 0.1mg/mL

CD1a / HTA1 (Mature Langerhans Cells Marker) (C1A/1506R) Antibody

BNCH1506-100 100uL
EUR 238.8
Description: Primary antibody against CD1a / HTA1 (Mature Langerhans Cells Marker) (C1A/1506R),Horseradish Peroxidase conjugate, Concentration: 0.1mg/mL

CD1a / HTA1 (Mature Langerhans Cells Marker) (C1A/1506R) Antibody

BNCH1506-500 500uL
EUR 652.8
Description: Primary antibody against CD1a / HTA1 (Mature Langerhans Cells Marker) (C1A/1506R),Horseradish Peroxidase conjugate, Concentration: 0.1mg/mL

CD1a / HTA1 (Mature Langerhans Cells Marker) (C1A/1506R) Antibody

BNCP1506-250 250uL
EUR 459.6
Description: Primary antibody against CD1a / HTA1 (Mature Langerhans Cells Marker) (C1A/1506R),PerCP conjugate, Concentration: 0.1mg/mL

CD1a / HTA1 (Mature Langerhans Cells Marker) (C1A/1506R) Antibody

BNCB1506-100 100uL
EUR 238.8
Description: Primary antibody against CD1a / HTA1 (Mature Langerhans Cells Marker) (C1A/1506R),Biotin conjugate, Concentration: 0.1mg/mL

CD1a / HTA1 (Mature Langerhans Cells Marker) (C1A/1506R) Antibody

BNCB1506-500 500uL
EUR 652.8
Description: Primary antibody against CD1a / HTA1 (Mature Langerhans Cells Marker) (C1A/1506R),Biotin conjugate, Concentration: 0.1mg/mL

CD1a / HTA1 (Mature Langerhans Cells Marker) (C1A/1506R) Antibody

BNUB1506-100 100uL
EUR 250.8
Description: Primary antibody against CD1a / HTA1 (Mature Langerhans Cells Marker) (C1A/1506R), Concentration: 0.2mg/mL

CD1a / HTA1 (Mature Langerhans Cells Marker) (C1A/1506R) Antibody

BNUB1506-500 500uL
EUR 549.6
Description: Primary antibody against CD1a / HTA1 (Mature Langerhans Cells Marker) (C1A/1506R), Concentration: 0.2mg/mL

CD1a / HTA1 (Mature Langerhans Cells Marker) (C1A/1506R) Antibody

BNUM1506-50 50uL
EUR 474
Description: Primary antibody against CD1a / HTA1 (Mature Langerhans Cells Marker) (C1A/1506R), 1mg/mL

CD1a / HTA1 (Mature Langerhans Cells Marker) (C1A/1506R) Antibody

BNC471506-100 100uL
EUR 238.8
Description: Primary antibody against CD1a / HTA1 (Mature Langerhans Cells Marker) (C1A/1506R),CF647 conjugate, Concentration: 0.1mg/mL

CD1a / HTA1 (Mature Langerhans Cells Marker) (C1A/1506R) Antibody

BNC471506-500 500uL
EUR 652.8
Description: Primary antibody against CD1a / HTA1 (Mature Langerhans Cells Marker) (C1A/1506R),CF647 conjugate, Concentration: 0.1mg/mL

CD1a / HTA1 (Mature Langerhans Cells Marker) (C1A/1506R) Antibody

BNC611506-100 100uL
EUR 238.8
Description: Primary antibody against CD1a / HTA1 (Mature Langerhans Cells Marker) (C1A/1506R),CF660R conjugate, Concentration: 0.1mg/mL

CD1a / HTA1 (Mature Langerhans Cells Marker) (C1A/1506R) Antibody

BNC611506-500 500uL
EUR 652.8
Description: Primary antibody against CD1a / HTA1 (Mature Langerhans Cells Marker) (C1A/1506R),CF660R conjugate, Concentration: 0.1mg/mL

CD1a / HTA1 (Mature Langerhans Cells Marker) (C1A/1506R) Antibody

BNC431506-100 100uL
EUR 238.8
Description: Primary antibody against CD1a / HTA1 (Mature Langerhans Cells Marker) (C1A/1506R),CF543 conjugate, Concentration: 0.1mg/mL

CD1a / HTA1 (Mature Langerhans Cells Marker) (C1A/1506R) Antibody

BNC431506-500 500uL
EUR 652.8
Description: Primary antibody against CD1a / HTA1 (Mature Langerhans Cells Marker) (C1A/1506R),CF543 conjugate, Concentration: 0.1mg/mL

CD1a / HTA1 (Mature Langerhans Cells Marker) (C1A/1506R) Antibody

BNC551506-100 100uL
EUR 238.8
Description: Primary antibody against CD1a / HTA1 (Mature Langerhans Cells Marker) (C1A/1506R),CF555 conjugate, Concentration: 0.1mg/mL

CD1a / HTA1 (Mature Langerhans Cells Marker) (C1A/1506R) Antibody

BNC551506-500 500uL
EUR 652.8
Description: Primary antibody against CD1a / HTA1 (Mature Langerhans Cells Marker) (C1A/1506R),CF555 conjugate, Concentration: 0.1mg/mL

CD1a / HTA1 (Mature Langerhans Cells Marker) (C1A/1506R) Antibody

BNC681506-100 100uL
EUR 238.8
Description: Primary antibody against CD1a / HTA1 (Mature Langerhans Cells Marker) (C1A/1506R),CF568 conjugate, Concentration: 0.1mg/mL

CD1a / HTA1 (Mature Langerhans Cells Marker) (C1A/1506R) Antibody

BNC681506-500 500uL
EUR 652.8
Description: Primary antibody against CD1a / HTA1 (Mature Langerhans Cells Marker) (C1A/1506R),CF568 conjugate, Concentration: 0.1mg/mL

Anti-CD1a / HTA1 (Mature Langerhans Cells Marker) Monoclonal Antibody

M00375 100ug/vial
EUR 476.4
Description: Mouse Monoclonal CD1a / HTA1 (Mature Langerhans Cells Marker) Antibody. Validated in IHC and tested in Human.

Monoclonal CD1a (Mature Langerhans Cells Marker) Antibody, Clone: SPM120

AMM01440G 7 ml
EUR 580.8
Description: A Monoclonal antibody against Human CD1a (Mature Langerhans Cells Marker). The antibodies are raised in Mouse and are from clone SPM120. This antibody is applicable in IHC, IF, FC

Monoclonal CD1a / HTA1 (Mature Langerhans Cells Marker) Antibody, Clone: O10

AMM01439G 7 ml
EUR 580.8
Description: A Monoclonal antibody against Human CD1a / HTA1 (Mature Langerhans Cells Marker). The antibodies are raised in Mouse and are from clone O10. This antibody is applicable in IHC, IF, FC

Monoclonal CD1a / HTA1 (Mature Langerhans Cells Marker) Antibody, Clone: C1A/711

AMM01441G 7 ml
EUR 580.8
Description: A Monoclonal antibody against Human CD1a / HTA1 (Mature Langerhans Cells Marker). The antibodies are raised in Mouse and are from clone C1A/711. This antibody is applicable in IHC, IF, FC

Monoclonal CD1a / HTA1 (Mature Langerhans Cells Marker) Antibody, Clone: O10 + C1A/711

AMM01442G 7 ml
EUR 580.8
Description: A Monoclonal antibody against Human CD1a / HTA1 (Mature Langerhans Cells Marker). The antibodies are raised in Mouse and are from clone O10 + C1A/711. This antibody is applicable in IHC, IF, FC

Monoclonal CD1a (Mature Langerhans Cells Marker) Antibody - With BSA and Azide, Clone: SPM120

AMM00439G 0.05mg
EUR 475.2
Description: A Monoclonal antibody against Human CD1a (Mature Langerhans Cells Marker) - With BSA and Azide. The antibodies are raised in Mouse and are from clone SPM120. This antibody is applicable in IHC-P, IF, FC

CD1a / HTA1 (Mature Langerhans Cells Marker); Clone O10 (Concentrate)

RA0031-C.1 0.1 ml
EUR 150

CD1a / HTA1 (Mature Langerhans Cells Marker); Clone O10 (Concentrate)

RA0031-C.5 0.5 ml
EUR 360

Monoclonal CD1a / HTA1 (Mature Langerhans Cells Marker) Antibody - With BSA and Azide, Clone: CBT6

AMM01445G 0.05mg
EUR 475.2
Description: A Monoclonal antibody against Human CD1a / HTA1 (Mature Langerhans Cells Marker) - With BSA and Azide. The antibodies are raised in Mouse and are from clone CBT6. This antibody is applicable in IF, FC

Monoclonal CD1a / HTA1 (Mature Langerhans Cells Marker) Antibody - With BSA and Azide, Clone: O10

AMM00172G 0.05mg
EUR 475.2
Description: A Monoclonal antibody against Human CD1a / HTA1 (Mature Langerhans Cells Marker) - With BSA and Azide. The antibodies are raised in Mouse and are from clone O10. This antibody is applicable in WB, IHC and IF, FC, IP, E

Monoclonal CD1a (Mature Langerhans Cells Marker) Antibody - Without BSA and Azide, Clone: SPM120

AMM00440G 0.1mg
EUR 580.8
Description: A Monoclonal antibody against Human CD1a (Mature Langerhans Cells Marker) - Without BSA and Azide. The antibodies are raised in Mouse and are from clone SPM120. This antibody is applicable in IHC-P, IF, FC

Monoclonal CD1a / HTA1 (Mature Langerhans Cells Marker) Antibody - With BSA and Azide, Clone: 66IIC7

AMM01443G 0.05mg
EUR 475.2
Description: A Monoclonal antibody against Human CD1a / HTA1 (Mature Langerhans Cells Marker) - With BSA and Azide. The antibodies are raised in Mouse and are from clone 66IIC7. This antibody is applicable in IHC, IF, FC

Monoclonal CD1a / HTA1 (Mature Langerhans Cells Marker) Antibody - Without BSA and Azide, Clone: O10

AMM00438G 0.1mg
EUR 580.8
Description: A Monoclonal antibody against Human CD1a / HTA1 (Mature Langerhans Cells Marker) - Without BSA and Azide. The antibodies are raised in Mouse and are from clone O10. This antibody is applicable in IHC-P, IF, FC

Monoclonal CD1a / HTA1 (Mature Langerhans Cells Marker) Antibody - With BSA and Azide, Clone: C1A/711

AMM00073G 0.05mg
EUR 475.2
Description: A Monoclonal antibody against Human CD1a / HTA1 (Mature Langerhans Cells Marker) - With BSA and Azide. The antibodies are raised in Mouse and are from clone C1A/711. This antibody is applicable in WB, IHC and IF, FC, IP, E

CD1a / HTA1 (Mature Langerhans Cells Marker); Clone C1A/711 (Concentrate)

RA0032-C.1 0.1 ml
EUR 150

CD1a / HTA1 (Mature Langerhans Cells Marker); Clone C1A/711 (Concentrate)

RA0032-C.5 0.5 ml
EUR 360

Monoclonal CD1a / HTA1 (Mature Langerhans Cells Marker) Antibody - Without BSA and Azide, Clone: CBT6

AMM01446G 0.1mg
EUR 580.8
Description: A Monoclonal antibody against Human CD1a / HTA1 (Mature Langerhans Cells Marker) - Without BSA and Azide. The antibodies are raised in Mouse and are from clone CBT6. This antibody is applicable in IF, FC

Monoclonal CD1a / HTA1 (Mature Langerhans Cells Marker) Antibody - Without BSA and Azide, Clone: C1A/711

AMM00441G 0.1mg
EUR 580.8
Description: A Monoclonal antibody against Human CD1a / HTA1 (Mature Langerhans Cells Marker) - Without BSA and Azide. The antibodies are raised in Mouse and are from clone C1A/711. This antibody is applicable in IHC-P, IF, FC

Monoclonal CD1a / HTA1 (Mature Langerhans Cells Marker) Antibody - With BSA and Azide, Clone: O10+C1A/711

AMM00173G 0.05mg
EUR 475.2
Description: A Monoclonal antibody against Human CD1a / HTA1 (Mature Langerhans Cells Marker) - With BSA and Azide. The antibodies are raised in Mouse and are from clone O10+C1A/711. This antibody is applicable in WB, IHC and IF, FC, IP

Monoclonal CD1a / HTA1 (Mature Langerhans Cells Marker) Antibody - Without BSA and Azide, Clone: 66IIC7

AMM01444G 0.1mg
EUR 580.8
Description: A Monoclonal antibody against Human CD1a / HTA1 (Mature Langerhans Cells Marker) - Without BSA and Azide. The antibodies are raised in Mouse and are from clone 66IIC7. This antibody is applicable in IHC, IF, FC

CD1a / HTA1 (Mature Langerhans Cells Marker); Clone O10 & C1A/711 (Concentrate)

RA0033-C.1 0.1 ml
EUR 150

CD1a / HTA1 (Mature Langerhans Cells Marker); Clone O10 & C1A/711 (Concentrate)

RA0033-C.5 0.5 ml
EUR 360

Monoclonal CD1a / HTA1 (Mature Langerhans Cells Marker) Antibody - Without BSA and Azide, Clone: O10 + C1A/711

AMM00442G 0.1mg
EUR 580.8
Description: A Monoclonal antibody against Human CD1a / HTA1 (Mature Langerhans Cells Marker) - Without BSA and Azide. The antibodies are raised in Mouse and are from clone O10 + C1A/711. This antibody is applicable in IHC-P, IF, FC

Anti-Guinea pig lymphocytes antibody

STJ16100971 1 mg
EUR 674.4

Islets of Langerhans, Peptide Aptamer, unlabeled

AP-317-U 5 mg Ask for price

Islets of Langerhans, Peptide Aptamer, Biotinylated

AP-317-B 1 mg Ask for price

Islets of Langerhans, Peptide Aptamer, FITC labelled

AP-317-F 1 mg Ask for price

Immortalized Bovine Lymphocytes- SV40

T0130 1x106 cells / 1.0 ml Ask for price

anti-CD26 T/B lymphocytes and macrophages

512-A-01mg 0,1 mg
EUR 321
Description: anti-CD26 Activated T, B lymphocytes and macrophages

anti-CD26 T/B lymphocytes and macrophages

512-A-1000ug 1000 ug
EUR 1539
Description: anti-CD26 Activated T, B lymphocytes and macrophages

anti-CD26 Activated T, B lymphocytes and macrophages

512-A-100ugvial 100 ug/vial
EUR 150
Description: anti-CD26 Activated T, B lymphocytes and macrophages

Human B lymphocyte / GFP Stable Cells

SC060-G 2 x 106 cell/ml x 1ml
EUR 2670
Description: RFP expression stable cell line in Human B lymphocyte cells with Puromycin resistance

Human B lymphocyte / RFP Stable Cells

SC060-R 2 x 106 cell/ml x 1ml
EUR 2670
Description: GFP expression stable cell line in Human B lymphocyte cells with Puromycin resistance

Human  Peripheral  Blood  CD4+  T  Lymphocytes, Fresh

PBCD4-F10M - Ask for price

Human  Peripheral  Blood  CD4+  T  Lymphocytes, Fresh

PBCD4-F20M - Ask for price

Human  Peripheral  Blood  CD4+  T  Lymphocytes, Cryopreserved

PBCD4-C10M - Ask for price

Human B lymphocyte (Luciferase / GFP) Stable Cells

SC060-LG 2 x 106 cell/ml x 1ml
EUR 3540
Description: Luciferase & GFP expression stable cell line in Human B lymphocyte cells with Puromycin resistance

Human B lymphocyte (Luciferase / RFP) Stable Cells

SC060-LR 2 x 106 cell/ml x 1ml
EUR 3540
Description: Luciferase & RFP expression stable cell line in Human B lymphocyte cells with Puromycin resistance

Rat Lymphocyte antibody

20R-LR004 20 mg
EUR 392.4
Description: Rabbit polyclonal Rat Lymphocyte antibody

Rat Lymphocyte antibody

20R-LR007 20 ml
EUR 1066.8
Description: Rabbit polyclonal Rat Lymphocyte antibody

Mouse Lymphocyte antibody

20R-LR005 20 mg
EUR 392.4
Description: Rabbit polyclonal Mouse Lymphocyte antibody

Mouse Lymphocyte antibody

20R-LR010 2 ml
EUR 405.6
Description: Rabbit polyclonal Mouse Lymphocyte antibody

Mouse Lymphocyte antibody

20R-LR013 20 mg
EUR 625.2
Description: Rabbit polyclonal Mouse Lymphocyte antibody

Mouse Lymphocyte antibody

20R-LR014 2 ml
EUR 289.2
Description: Rabbit polyclonal Mouse Lymphocyte antibody

Rat Lymphocyte antibody (FITC)

60R-LR002FT 2 mg
EUR 438
Description: Rabbit polyclonal Rat Lymphocyte antibody (FITC) conjugated

Hamster Lymphocyte antibody

20R-LR011 20 mg
EUR 392.4
Description: Rabbit polyclonal Hamster Lymphocyte antibody

Hamster Lymphocyte antibody

20R-LR012 2 ml
EUR 289.2
Description: Rabbit polyclonal Hamster Lymphocyte antibody

Mouse Lymphocyte antibody (FITC)

60R-LR003FT 2 mg
EUR 438
Description: Rabbit polyclonal Mouse Lymphocyte antibody (FITC) conjugated

BLK Antibody / B lymphocyte kinase

F54943-0.08ML 0.08 ml
EUR 140.25
Description: Protein kinases are enzymes that transfer a phosphate group from a phosphate donor, generally the g phosphate of ATP, onto an acceptor amino acid in a substrate protein. By this basic mechanism, protein kinases mediate most of the signal transduction in eukaryotic cells, regulating cellular metabolism, transcription, cell cycle progression, cytoskeletal rearrangement and cell movement, apoptosis, and differentiation. With more than 500 gene products, the protein kinase family is one of the largest families of proteins in eukaryotes. The family has been classified in 8 major groups based on sequence comparison of their tyrosine (PTK) or serine/threonine (STK) kinase catalytic domains. The STE group (homologs of yeast Sterile 7, 11, 20 kinases) consists of 50 kinases related to the mitogen-activated protein kinase (MAPK) cascade families (Ste7/MAP2K, Ste11/MAP3K, and Ste20/MAP4K). MAP kinase cascades, consisting of a MAPK and one or more upstream regulatory kinases (MAPKKs) have been best characterized in the yeast pheromone response pathway. Pheromones bind to Ste cell surface receptors and activate yeast MAPK pathway.

BLK Antibody / B lymphocyte kinase

F54943-0.4ML 0.4 ml
EUR 322.15
Description: Protein kinases are enzymes that transfer a phosphate group from a phosphate donor, generally the g phosphate of ATP, onto an acceptor amino acid in a substrate protein. By this basic mechanism, protein kinases mediate most of the signal transduction in eukaryotic cells, regulating cellular metabolism, transcription, cell cycle progression, cytoskeletal rearrangement and cell movement, apoptosis, and differentiation. With more than 500 gene products, the protein kinase family is one of the largest families of proteins in eukaryotes. The family has been classified in 8 major groups based on sequence comparison of their tyrosine (PTK) or serine/threonine (STK) kinase catalytic domains. The STE group (homologs of yeast Sterile 7, 11, 20 kinases) consists of 50 kinases related to the mitogen-activated protein kinase (MAPK) cascade families (Ste7/MAP2K, Ste11/MAP3K, and Ste20/MAP4K). MAP kinase cascades, consisting of a MAPK and one or more upstream regulatory kinases (MAPKKs) have been best characterized in the yeast pheromone response pathway. Pheromones bind to Ste cell surface receptors and activate yeast MAPK pathway.

Lymphocyte Antigen 9 (LY9) Antibody

20-abx135950
  • EUR 493.20
  • EUR 710.40
  • EUR 218.40
  • EUR 376.80
  • 100 ul
  • 200 ul
  • 20 ul
  • 50 ul

Lymphocyte Antigen 9 (LY9) Antibody

20-abx173394
  • EUR 978.00
  • EUR 510.00
  • 1 mg
  • 200 ug

Lymphocyte Antigen 9 (LY9) Antibody

20-abx321213
  • EUR 526.80
  • EUR 393.60
  • 100 ul
  • 50 ul

Lymphocyte Antigen 9 (LY9) Antibody

20-abx101895
  • EUR 493.20
  • EUR 159.60
  • EUR 1378.80
  • EUR 678.00
  • EUR 376.80
  • 100 ug
  • 10 ug
  • 1 mg
  • 200 ug
  • 50 ug

Lymphocyte Antigen 9 (LY9) Antibody

20-abx101896
  • EUR 510.00
  • EUR 159.60
  • EUR 1412.40
  • EUR 693.60
  • EUR 393.60
  • 100 ug
  • 10 ug
  • 1 mg
  • 200 ug
  • 50 ug

Lymphocyte Antigen 9 (LY9) Antibody

20-abx323650
  • EUR 376.80
  • EUR 292.80
  • 100 ug
  • 50 ug

Hamster Lymphocyte antibody (FITC)

60R-LR001FT 2 mg
EUR 438
Description: Rabbit polyclonal Hamster Lymphocyte antibody (FITC) conjugated

Lymphocyte Antigen 75 (Ly75) Antibody

20-abx319073
  • EUR 493.20
  • EUR 2214.00
  • EUR 718.80
  • EUR 218.40
  • EUR 360.00
  • 100 ug
  • 1 mg
  • 200 ug
  • 20 ug
  • 50 ug

Lymphocyte Antigen 75 (LY75) Antibody

20-abx135983
  • EUR 493.20
  • EUR 710.40
  • EUR 218.40
  • EUR 376.80
  • 100 ul
  • 200 ul
  • 20 ul
  • 50 ul

Lymphocyte Antigen 96 (LY96) Antibody

abx234900-100ug 100 ug
EUR 661.2

Lymphocyte Antigen 86 (LY86) Antibody

20-abx225271
  • EUR 444.00
  • EUR 727.20
  • EUR 376.80
  • 100 ul
  • 200 ul
  • 50 ul

Lymphocyte Antigen 96 (LY96) Antibody

20-abx225272
  • EUR 444.00
  • EUR 727.20
  • EUR 376.80
  • 100 ul
  • 200 ul
  • 50 ul

Lymphocyte Antigen 96 (LY96) Antibody

20-abx173395
  • EUR 1028.40
  • EUR 526.80
  • 1 mg
  • 200 ug

Lymphocyte Antigen 75 (LY75) Antibody

20-abx177391
  • EUR 1412.40
  • EUR 693.60
  • 1 mg
  • 200 ug

Lymphocyte Antigen 75 (LY75) Antibody

20-abx211432
  • EUR 493.20
  • EUR 360.00
  • 100 ul
  • 50 ul

Lymphocyte Antigen 96 (LY96) Antibody

20-abx212140
  • EUR 493.20
  • EUR 360.00
  • 100 ul
  • 50 ul

Lymphocyte Antigen 75 (LY75) Antibody

20-abx321263
  • EUR 526.80
  • EUR 393.60
  • 100 ul
  • 50 ul

Lymphocyte Antigen 75 (LY75) Antibody

20-abx322649
  • EUR 526.80
  • EUR 393.60
  • 100 ul
  • 50 ul

Lymphocyte Antigen 75 (LY75) Antibody

abx331030-100ul 100 ul
EUR 510

Lymphocyte Antigen 96 (LY96) Antibody

20-abx113544
  • EUR 878.40
  • EUR 477.60
  • 150 ul
  • 50 ul

Lymphocyte Antigen 96 (LY96) Antibody

abx029509-400ul 400 ul
EUR 627.6

Lymphocyte Antigen 96 (LY96) Antibody

abx029509-80l 80 µl
EUR 343.2

Lymphocyte Antigen 86 (LY86) Antibody

abx028333-400ul 400 ul
EUR 627.6

Lymphocyte Antigen 86 (LY86) Antibody

abx028333-80l 80 µl
EUR 343.2

Lymphocyte Antigen 96 (LY96) Antibody

20-abx102165
  • EUR 510.00
  • EUR 159.60
  • EUR 1446.00
  • EUR 693.60
  • EUR 393.60
  • 100 ug
  • 10 ug
  • 1 mg
  • 200 ug
  • 50 ug

Lymphocyte Antigen 96 (LY96) Antibody

20-abx102166
  • EUR 526.80
  • EUR 159.60
  • EUR 1479.60
  • EUR 710.40
  • EUR 393.60
  • 100 ug
  • 10 ug
  • 1 mg
  • 200 ug
  • 50 ug

Lymphocyte Antigen 75 (LY75) Antibody

20-abx129826
  • EUR 510.00
  • EUR 159.60
  • EUR 1412.40
  • EUR 693.60
  • EUR 393.60
  • 100 ug
  • 10 ug
  • 1 mg
  • 200 ug
  • 50 ug

Lymphocyte Antigen 75 (LY75) Antibody

20-abx323904
  • EUR 376.80
  • EUR 292.80
  • 100 ug
  • 50 ug

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